Calcium permeable stress-gated cation channel 1 (Transmembrane protein 63C)
1_MSASP 6_ DDLST 11_ GGRLQ 16_ NMTVD 21_ ECFQS 26_ RNTVL 31_ QGQPF 36_ GGVPT 41_ VLCLN 46_ IALWV 51_ LVLVV 56_ YSFLR 61_ KAAWD 66_ YGRLA 71_ LLIHN 76_ DSLTS 81_ LIYGE 86_ QSEKT 91_ SPSET 96_ SLEME 101_ RRDKG 106_ FCSWF 111_ FNSIT 116_ MKDED 121_ LINKC 126_ GDDAR 131_ IYIVF 136_ QYHLI 141_ IFVLI 146_ ICIPS 151_ LGIIL 156_ PINYT 161_ GSVLD 166_ WSSHF 171_ ARTTI 176_ VNVST 181_ ESKLL 186_ WLHSL 191_ LSFFY 196_ FITNF 201_ MFMAH 206_ HCLGF 211_ APRNS 216_ QKVTR 221_ TLMIT 226_ YVPKD 231_ IEDPE 236_ LIIKH 241_ FHEAY 246_ PGSVV 251_ TRVHF 256_ CYDVR 261_ NLIDL 266_ DDQRR 271_ HAMRG 276_ RLFYT 281_ AKAKK 286_ TGKVM 291_ IRIHP 296_ CARLC 301_ FCKCW 306_ TCFKE 311_ VDAEQ 316_ YYSEL 321_ EEQLT 326_ DEFNA 331_ ELNRV 336_ PLKRL 341_ DLIFV 346_ TFQDS 351_ RMAKR 356_ VRKDY 361_ KYVQC 366_ GVQPQ 371_ QSSVT 376_ TIVKS 381_ YYWRV 386_ TMAPH 391_ PKDII 396_ WKHLS 401_ VRRFF 406_ WWARF 411_ IAINT 416_ FLFFL 421_ FFFLT 426_ TPAII 431_ MNTID 436_ MYNVT 441_ RPIEK 446_ LQNPI 451_ VTQFF 456_ PSVML 461_ WGFTV 466_ ILPLI 471_ VYFSA 476_ FLEAH 481_ WTRSS 486_ QNLVM 491_ VHKCY 496_ IFLVF 501_ MVVIL 506_ PSMGL 511_ TSLDV 516_ FLRWL 521_ FDIYY 526_ LEQAS 531_ IRFQC 536_ VFLPD 541_ NGAFF 546_ VNYVI 551_ TAALL 556_ GTGME 561_ LLRLG 566_ SLFCY 571_ STRLF 576_ FSRSE 581_ PERVN 586_ IRKNQ 591_ AIDFQ 596_ FGREY 601_ AWMMN 606_ VFSVV 611_ MAYSI 616_ TCPII 621_ VPFGL 626_ LYLCM 631_ KHLTD 636_ RYNMY 641_ YSFAP 646_ TKLNE 651_ QIHMA 656_ AVSQA 661_ IFAPL 666_ LGLFW 671_ MLFFS 676_ ILRLG 681_ SLHAI 686_ TIFSL 691_ STLLI 696_ AMVIA 701_ FVGIF 706_ LGKLR 711_ MVADY 716_ EPEEE 721_ EIQTV 726_ FDMEP 731_ SSTSS 736_ TPTSL 741_ LYVAT 746_ VLQEP 751_ ELNLT 756_ PASSP 761_ ARHTY 766_ GTMNN 771_ QPEEG 776_ EEESG 781_ LRGFA 786_ RELDS 791_ AQFQE 796_ GLELE 801_GQNQY
1: Acts as an osmosensitive cation channel preferentially activated upon hypotonic stress (PubMed:24503647, PubMed:35718349). In contrast to TMEM63B, does not show phospholipid scramblase activity (PubMed:39716028). Enriched in mitochondria-ER contact sites where it may regulate the metabolite flux and organelles' morphologies in response to osmotic changes (PubMed:35718349). In particular may regulate mitochondrial motility and function in motor neuron axons (PubMed:35718349). Required for the functional integrity of the kidney glomerular filtration barrier (By similarity)