Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha)
1_MVEAA 6_ PPGPG 11_ PLRRT 16_ FLVPE 21_ IKSLD 26_ QYDFS 31_ RAKAA 36_ ASLAW 41_ VLRAA 46_ FGGAE 51_ HVPPE 56_ LWEPF 61_ YTDQY 66_ AQEHV 71_ KPPVT 76_ RLLLS 81_ AELYC 86_ RAWRQ 91_ ALPQL 96_ ETPPN 101_ PSALL 106_ ALLAR 111_ RGTVP 116_ ALPER 121_ PVREA 126_ DLRHQ 131_ PILMG 136_ AHLAV 141_ IDALM 146_ AAFAF 151_ EWTKT 156_ LPGPL 161_ ALTSL 166_ EHKLL 171_ FWVDT 176_ TVRRL 181_ QEKTE 186_ QEAAQ 191_ RASPA 196_ APADG 201_ AAPAQ 206_ PSIRY 211_ RKDRV 216_ VARRA 221_ PCFPT 226_ VTSLQ 231_ DLASG 236_ AALAA 241_ TIHCY 246_ CPQLL 251_ RLEEV 256_ CLKDP 261_ MSVAD 266_ SLYNL 271_ QLVQD 276_ FCASR 281_ LPRGC 286_ PLSLE 291_ DLLYV 296_ PPPLK 301_ VNLVV 306_ MLAEL 311_ FMCFE 316_ VLKPD 321_ FVQVK 326_ DLPDG 331_ HAASP 336_ RGTEA 341_ SPPQN 346_ NSGSS 351_ SPVFT 356_ FRHPL 361_ LSSGG 366_ PQSPL 371_ RGSTG 376_ SLKSS 381_ PSMSH 386_ MEALG 391_ KAWNR 396_ QLSRP 401_ LSQAV 406_ SFSTP 411_ FGLDS 416_ DVDVV 421_ MGDPV 426_ LLRSV 431_ SSDSL 436_ GPPRP 441_ APART 446_ PTQPP 451_ PEPGD 456_ LPTIE 461_ EALQI 466_ IHSAE 471_ PRLLP 476_ DGAAD 481_ GSFYL 486_ HSPEG 491_ PSKPS 496_ LASPY 501_ LPEGT 506_ SKPLS 511_ DRPTK 516_ APVYM 521_ PHPET 526_ PSKPS 531_ PCLVG 536_ EASKP 541_ PAPSE 546_ GSPKA 551_ VASSP 556_ AATNS 561_ EVKMT 566_ SFAER 571_ KKQLV 576_ KAEAE 581_ AGAGS 586_ PTSTP 591_ APPEA 596_ LSSEM 601_ SELSA 606_ RLEEK 611_ RRAIE 616_ AQKRR 621_ IEAIF 626_ AKHRQ 631_ RLGKS 636_ AFLQV 641_ QPREA 646_ SGEAE 651_ AEAEE 656_ ADSGP 661_ VPGGE 666_ RPAGE 671_ GQGEP 676_ TSRPK 681_ AVTFS 686_ PDLGP 691_ VPHEG 696_ LGEYN 701_ RAVSK 706_ LSAAL 711_ SSLQR 716_ DMQRL 721_ TDQQQ 726_ RLLAP 731_ PEAPG 736_ SAPPP 741_ AAWVI 746_ PGPTT 751_ GPKAA 756_ SPSPA 761_ RRVPA 766_ TRRSP 771_ GPGPS 776_ QSPRS 781_ PKHTR 786_ PAELR 791_ LAPLT 796_ RVLTP 801_ PHDVD 806_ SLPHL 811_ RKFSP 816_ SQVPV 821_ QTRSS 826_ ILLAE 831_ ETPPE 836_ EPAAR 841_ PGLIE 846_ IPLGS 851_ LADPA 856_ AEDEG 861_ DGSPA 866_ GAEDS 871_ LEEEA 876_ SSEGE 881_ PRVGL 886_ GFFYK 891_ DEDKP 896_ EDEMA 901_ QKRAS 906_ LLERQ 911_ QRRAE 916_ EARRR 921_ KQWQE 926_ VEKEQ 931_ RREEA 936_ ARLAQ 941_ EEAPG 946_ PAPLV 951_ SAVPM 956_ ATPAP 961_ AARAP 966_ AEEEV 971_ GPRKG 976_ DFTRQ 981_ EYERR 986_ AQLKL 991_ MDDLD 996_ KVLRP 1001_ RAAGS 1006_ GGPGR 1011_ GGRRA 1016_ TRPRS 1021_ GCCDD 1026_ SALAR 1031_ SPARG 1036_ LLGSR 1041_ LSKIY 1046_ SQSTL 1051_ SLSTV 1056_ ANEAH 1061_ NNLGV 1066_ KRPTS 1071_ RAPSP 1076_ SGLMS 1081_ PSRLP 1086_ GSRER 1091_ DWENG 1096_ SNASS 1101_ PASVP 1106_ EYTGP 1111_ RLYKE 1116_ PSAKS 1121_ NKFII 1126_ HNALS 1131_ HCCLA 1136_ GKVNE 1141_ PQKNR 1146_ ILEEI 1151_ EKSKA 1156_ NHFLI 1161_ LFRDS 1166_ SCQFR 1171_ ALYTL 1176_ SGETE 1181_ ELSRL 1186_ AGYGP 1191_ RTVTP 1196_ AMVEG 1201_ IYKYN 1206_ SDRKR 1211_ FTQIP 1216_ AKTMS 1221_ MSVDA 1226_ FTIQG 1231_ HLWQG 1236_ KKPTT 1241_PKKGG
1: Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742, PubMed:27802168). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity)