Zinc finger and BTB domain-containing protein 4 (KAISO-like zinc finger protein 1) (KAISO-L1)
1_MPPPA 6_ EVTDP 11_ SHAPA 16_ VLRQL 21_ NEQRL 26_ RGLFC 31_ DVTLI 36_ AGDTK 41_ FPAHR 46_ SVLAA 51_ SSPFF 56_ REALL 61_ TSAPL 66_ PLPPA 71_ TGGAA 76_ PNPAT 81_ TTAAS 86_ SSSSS 91_ SSSSS 96_ SSSSS 101_ ASSSS 106_ SSSSS 111_ SPPPA 116_ SPPAS 121_ SPPRV 126_ LELPG 131_ VPAAA 136_ FSDVL 141_ NFIYS 146_ ARLAL 151_ PGGGG 156_ DGAAV 161_ AEIGA 166_ LGRRL 171_ GISRL 176_ QGLGE 181_ GGDAW 186_ VPPTP 191_ APMAT 196_ SQPEE 201_ DSFGP 206_ GPRPA 211_ GEWEG 216_ DRAEA 221_ QAPDL 226_ QCSLP 231_ RRPLP 236_ CPQCG 241_ KSFIH 246_ PKRLQ 251_ THEAQ 256_ CRRGA 261_ STRGS 266_ TGLGA 271_ GGAGP 276_ GGPAG 281_ VDASA 286_ LPPPV 291_ GFRGG 296_ PEHVV 301_ KVVGG 306_ HVLYV 311_ CAACE 316_ RSYVT 321_ LSSLK 326_ RHSNV 331_ HSWRR 336_ KYPCR 341_ YCEKV 346_ FALAE 351_ YRTKH 356_ EVWHT 361_ GERRY 366_ QCIFC 371_ WETFV 376_ TYYNL 381_ KTHQR 386_ AFHGI 391_ SPGLL 396_ ASEKT 401_ PNGGY 406_ KPKLN 411_ TLKLY 416_ RLLPM 421_ RAAKR 426_ PYKTY 431_ SQGAP 436_ EAPLS 441_ PTLNT 446_ PAPVA 451_ MPASP 456_ PPGPP 461_ PAPEP 466_ GPPPS 471_ VITFA 476_ HPAPS 481_ VIVHG 486_ GSSSG 491_ GGGSG 496_ TASTG 501_ GSQAA 506_ SVITY 511_ TAPPR 516_ PPKKR 521_ EYPPP 526_ PPEPA 531_ ATPTS 536_ PATAV 541_ SPATA 546_ AGPAM 551_ ATTTE 556_ EAKGR 561_ NPRAG 566_ RTLTY 571_ TAKPV 576_ GGIGG 581_ GGGPP 586_ TGAGR 591_ GPSQL 596_ QAPPP 601_ LCQIT 606_ VRIGE 611_ EAIVK 616_ RRISE 621_ TDLRP 626_ GELSG 631_ EEMEE 636_ SEEDE 641_ EEEDE 646_ EEEEE 651_ DEEES 656_ KAGGE 661_ DQLWR 666_ PYYSY 671_ KPKRK 676_ AGAAG 681_ GASVG 686_ GSGLP 691_ RGRRP 696_ PRWRQ 701_ KLERR 706_ SWEET 711_ PAAES 716_ PAGRA 721_ RTERR 726_ HRCGD 731_ CAQTF 736_ TTLRK 741_ LRKHQ 746_ EAHGG 751_ GSHSS 756_ RAGRR 761_ PSTRF 766_ TCPHC 771_ AKVCK 776_ TAAAL 781_ SRHGQ 786_ RHAAE 791_ RPGGT 796_ PTPVI 801_ AYSKG 806_ SAGTR 811_ PGDVK 816_ EEAPQ 821_ EMQVS 826_ SSSGE 831_ AGGGS 836_ TAAEE 841_ ASETA 846_ SLQDP 851_ IISGG 856_ EEPPV 861_ VASGG 866_ SYVYP 871_ PVQEF 876_ PLALI 881_ GGGRE 886_ PGGGR 891_ GKSGS 896_ EGPVG 901_ AGEGD 906_ RMEGI 911_ GAAKV 916_ TFYPE 921_ PYPLV 926_ YGPQL 931_ LAAYP 936_ YNFSN 941_ LAALP 946_ VALNM 951_ VLPDE 956_ KGAGA 961_ LPFLP 966_ GVFGY 971_ AVNPQ 976_ AAPPA 981_ PPTPP 986_ PPTLP 991_ PPIPP 996_ KGEGE 1001_ RAGVE 1006_RTQKG
1: Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA (PubMed:16354688). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity)