Calcium-binding and coiled-coil domain-containing protein 1 (Calphoglin) (Coiled-coil coactivator protein) (Sarcoma antigen NY-SAR-3)
1_MEESP 6_ LSRAP 11_ SRGGV 16_ NFLNV 21_ ARTYI 26_ PNTKV 31_ ECHYT 36_ LPPGT 41_ MPSAS 46_ DWIGI 51_ FKVEA 56_ ACVRD 61_ YHTFV 66_ WSSVP 71_ ESTTD 76_ GSPIH 81_ TSVQF 86_ QASYL 91_ PKPGA 96_ QLYQF 101_ RYVNR 106_ QGQVC 111_ GQSPP 116_ FQFRE 121_ PRPMD 126_ ELVTL 131_ EEADG 136_ GSDIL 141_ LVVPK 146_ ATVLQ 151_ NQLDE 156_ SQQER 161_ NDLMQ 166_ LKLQL 171_ EGQVT 176_ ELRSR 181_ VQELE 186_ RALAT 191_ ARQEH 196_ TELME 201_ QYKGI 206_ SRSHG 211_ EITEE 216_ RDILS 221_ RQQGD 226_ HVARI 231_ LELED 236_ DIQTI 241_ SEKVL 246_ TKEVE 251_ LDRLR 256_ DTVKA 261_ LTREQ 266_ EKLLG 271_ QLKEV 276_ QADKE 281_ QSEAE 286_ LQVAQ 291_ QENHH 296_ LNLDL 301_ KEAKS 306_ WQEEQ 311_ SAQAQ 316_ RLKDK 321_ VAQMK 326_ DTLGQ 331_ AQQRV 336_ AELEP 341_ LKEQL 346_ RGAQE 351_ LAASS 356_ QQKAT 361_ LLGEE 366_ LASAA 371_ AARDR 376_ TIAEL 381_ HRSRL 386_ EVAEV 391_ NGRLA 396_ ELGLH 401_ LKEEK 406_ CQWSK 411_ ERAGL 416_ LQSVE 421_ AEKDK 426_ ILKLS 431_ AEILR 436_ LEKAV 441_ QEERT 446_ QNQVF 451_ KTELA 456_ REKDS 461_ SLVQL 466_ SESKR 471_ ELTEL 476_ RSALR 481_ VLQKE 486_ KEQLQ 491_ EEKQE 496_ LLEYM 501_ RKLEA 506_ RLEKV 511_ ADEKW 516_ NEDAT 521_ TEDEE 526_ AAVGL 531_ SCPAA 536_ LTDSE 541_ DESPE 546_ DMRLP 551_ PYGLC 556_ ERGDP 561_ GSSPA 566_ GPREA 571_ SPLVV 576_ ISQPA 581_ PISPH 586_ LSGPA 591_ EDSSS 596_ DSEAE 601_ DEKSV 606_ LMAAV 611_ QSGGE 616_ EANLL 621_ LPELG 626_ SAFYD 631_ MASGF 636_ TVGTL 641_ SETST 646_ GGPAT 651_ PTWKE 656_ CPICK 661_ ERFPA 666_ ESDKD 671_ ALEDH 676_ MDGHF 681_ FFSTQ 686_DPFTF
1: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781)
2: Seems to enhance inorganic pyrophosphatase thus activating phosphogluomutase (PMG). Probably functions as a component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth