Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
1_MEAEQ 6_ RPAAG 11_ ASEGA 16_ TPGLE 21_ AVPPV 26_ APPPA 31_ TAASG 36_ PIPKS 41_ GPEPK 46_ RRHLG 51_ TLLQP 56_ TVNKF 61_ SLRVF 66_ GSHKA 71_ VEIEQ 76_ ERVKS 81_ AGAWI 86_ IHPYS 91_ DFRFY 96_ WDLIM 101_ LLLMV 106_ GNLIV 111_ LPVGI 116_ TFFKE 121_ ENSPP 126_ WIVFN 131_ VLSDT 136_ FFLLD 141_ LVLNF 146_ RTGIV 151_ VEEGA 156_ EILLA 161_ PRAIR 166_ TRYLR 171_ TWFLV 176_ DLISS 181_ IPVDY 186_ IFLVV 191_ ELEPR 196_ LDAEV 201_ YKTAR 206_ ALRIV 211_ RFTKI 216_ LSLLR 221_ LLRLS 226_ RLIRY 231_ IHQWE 236_ EIFHM 241_ TYDLA 246_ SAVVR 251_ IFNLI 256_ GMMLL 261_ LCHWD 266_ GCLQF 271_ LVPML 276_ QDFPP 281_ DCWVS 286_ INHMV 291_ NHSWG 296_ RQYSH 301_ ALFKA 306_ MSHML 311_ CIGYG 316_ QQAPV 321_ GMPDV 326_ WLTML 331_ SMIVG 336_ ATCYA 341_ MFIGH 346_ ATALI 351_ QSLDS 356_ SRRQY 361_ QEKYK 366_ QVEQY 371_ MSFHK 376_ LPADT 381_ RQRIH 386_ EYYEH 391_ RYQGK 396_ MFDEE 401_ SILGE 406_ LSEPL 411_ REEII 416_ NFTCR 421_ GLVAH 426_ MPLFA 431_ HADPS 436_ FVTAV 441_ LTKLR 446_ FEVFQ 451_ PGDLV 456_ VREGS 461_ VGRKM 466_ YFIQH 471_ GLLSV 476_ LARGA 481_ RDTRL 486_ TDGSY 491_ FGEIC 496_ LLTRG 501_ RRTAS 506_ VRADT 511_ YCRLY 516_ SLSVD 521_ HFNAV 526_ LEEFP 531_ MMRRA 536_ FETVA 541_ MDRLL 546_ RIGKK 551_ NSILQ 556_ RKRSE 561_ PSPGS 566_ SGGIM 571_ EQHLV 576_ QHDRD 581_ MARGV 586_ RGRAP 591_ STGAQ 596_ LSGKP 601_ VLWEP 606_ LVHAP 611_ LQAAA 616_ VTSNV 621_ AIALT 626_ HQRGP 631_ LPLSP 636_ DSPAT 641_ LLARS 646_ AWRSA 651_ GSPAS 656_ PLVPV 661_ RAGPW 666_ ASTSR 671_ LPAPP 676_ ARTLH 681_ ASLSR 686_ AGRSQ 691_ VSLLG 696_ PPPGG 701_ GGRRL 706_ GPRGR 711_ PLSAS 716_ QPSLP 721_ QRATG 726_ DGSPG 731_ RKGSG 736_ SERLP 741_ PSGLL 746_ AKPPR 751_ TAQPP 756_ RPPVP 761_ EPATP 766_RGLQL
1: Hyperpolarization-activated ion channel that are permeable to sodium and potassium ions, with an about 3:1 preference for potassium ions (PubMed:16043489). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). In particular, plays a pivotal role in maintaining excitability and promoting rhythmic burst firing within hypothalamic nuclei. Exerts a significant influence on the configuration of the cardiac action potential waveform. Does not appear to play a prominent role in the processing of acute, neuropathic, or inflammatory pain (By similarity)