1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Pancreas-enriched phospholipase C) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1)
1_MTSEE 6_ MTASV 11_ LIPVT 16_ QRKVV 21_ SAQSA 26_ ADESS 31_ EKVSD 36_ INISK 41_ AHTVR 46_ RSGET 51_ SHTIS 56_ QLNKL 61_ KEEPS 66_ GSNLP 71_ KILSI 76_ AREKI 81_ VSDEN 86_ SNEKC 91_ WEKIM 96_ PDSAK 101_ NLNIN 106_ CNNIL 111_ RNHQH 116_ GLPQR 121_ QFYEM 126_ YNSVA 131_ EEDLC 136_ LETGI 141_ PSPLE 146_ RKVFP 151_ GIQLE 156_ LDRPS 161_ MGISP 166_ LGNQS 171_ VIIET 176_ GRAHP 181_ DSRRA 186_ VFHFH 191_ YEVDR 196_ RMSDT 201_ FCTLS 206_ ENLIL 211_ DDCGN 216_ CVPLP 221_ GGEEK 226_ QKKNY 231_ VAYTC 236_ KLMEL 241_ AKNCD 246_ NKNEQ 251_ LQCDH 256_ CDTLN 261_ DKYFC 266_ FEGSC 271_ EKVDM 276_ VYSGD 281_ SFCRK 286_ DFTDS 291_ QAAKT 296_ FLSHF 301_ EDFPD 306_ NCDDV 311_ EEDAF 316_ KSKKE 321_ RSTLL 326_ VRRFC 331_ KNDRE 336_ VKKSV 341_ YTGTR 346_ AIVRT 351_ LPSGH 356_ IGLTA 361_ WSYID 366_ QKRNG 371_ PLLPC 376_ GRVME 381_ PPSTV 386_ EIRQD 391_ GSQRL 396_ SEAQW 401_ YPIYN 406_ AVRRE 411_ ETENT 416_ VGSLL 421_ HFLTK 426_ LPASE 431_ TAHGR 436_ ISVGP 441_ CLKQC 446_ VRDTV 451_ CEYRA 456_ TLQRT 461_ SISQY 466_ ITGSL 471_ LEATT 476_ SLGAR 481_ SGLLS 486_ TFGGS 491_ TGRMM 496_ LKERQ 501_ PGPSV 506_ ANSNA 511_ LPSSS 516_ AGISK 521_ ELIDL 526_ QPLIQ 531_ FPEEV 536_ ASILM 541_ EQEQT 546_ IYRRV 551_ LPVDY 556_ LCFLT 561_ RDLGT 566_ PECQS 571_ SLPCL 576_ KASIS 581_ ASILT 586_ TQNGE 591_ HNALE 596_ DLVMR 601_ FNEVS 606_ SWVTW 611_ LILTA 616_ GSMEE 621_ KREVF 626_ SYLVH 631_ VAKCC 636_ WNMGN 641_ YNAVM 646_ EFLAG 651_ LRSRK 656_ VLKMW 661_ QFMDQ 666_ SDIET 671_ MRSLK 676_ DAMAQ 681_ HESSC 686_ EYRKV 691_ VTRAL 696_ HIPGC 701_ KVVPF 706_ CGVFL 711_ KELCE 716_ VLDGA 721_ SGLMK 726_ LCPRY 731_ NSQEE 736_ TLEFV 741_ ADYSG 746_ QDNFL 751_ QRVGQ 756_ NGLKN 761_ SEKES 766_ TVNSI 771_ FQVIR 776_ SCNRS 781_ LETDE 786_ EDSPS 791_ EGNSS 796_ RKSSL 801_ KDKSR 806_ WQFII 811_ GDLLD 816_ SDNDI 821_ FEQSK 826_ EYDSH 831_ GSEDS 836_ QKAFD 841_ HGTEL 846_ IPWYV 851_ LSIQA 856_ DVHQF 861_ LLQGA 866_ TVIHY 871_ DQDTH 876_ LSARC 881_ FLQLQ 886_ PDNST 891_ LTWVK 896_ PTTAS 901_ PASSK 906_ AKLGV 911_ LNNTA 916_ EPGKF 921_ PLLGN 926_ AGLSS 931_ LTEGV 936_ LDLFA 941_ VKAVY 946_ MGHPG 951_ IDIHT 956_ VCVQN 961_ KLGSM 966_ FLSET 971_ GVTLL 976_ YGLQT 981_ TDNRL 986_ LHFVA 991_ PKHTA 996_ KMLFS 1001_ GLLEL 1006_ TRAVR 1011_ KMRKF 1016_ PDQRQ 1021_ QWLRK 1026_ QYVSL 1031_ YQEDG 1036_ RYEGP 1041_ TLAHA 1046_ VELFG 1051_ GRRWS 1056_ ARNPS 1061_ PGTSA 1066_ KNAEK 1071_ PNMQR 1076_ NNTLG 1081_ ISTTK 1086_ KKKKI 1091_ LMRGE 1096_ SGEVT 1101_ DDEMA 1106_ TRKAK 1111_ MHKEC 1116_ RSRSG 1121_ SDPQD 1126_ INEQE 1131_ ESEVN 1136_ AIANP 1141_ PNPLP 1146_ SRRAH 1151_ SLTTA 1156_ GSPNL 1161_ AAGTS 1166_ SPIRP 1171_ VSSPV 1176_ LSSSN 1181_ KSPSS 1186_ AWSSS 1191_ SWHGR 1196_ IKGGM 1201_ KGFQS 1206_ FMVSD 1211_ SNMSF 1216_ VEFVE 1221_ LFKSF 1226_ SVRSR 1231_ KDLKD 1236_ LFDVY 1241_ AVPCN 1246_ RSGSE 1251_ SAPLY 1256_ TNLTI 1261_ DENTS 1266_ DLQPD 1271_ LDLLT 1276_ RNVSD 1281_ LGLFI 1286_ KSKQQ 1291_ LSDNQ 1296_ RQISD 1301_ AIAAA 1306_ SIVTN 1311_ GTGIE 1316_ STSLG 1321_ IFGVG 1326_ ILQLN 1331_ DFLVN 1336_ CQGEH 1341_ CTYDE 1346_ ILSII 1351_ QKFEP 1356_ SISMC 1361_ HQGLM 1366_ SFEGF 1371_ ARFLM 1376_ DKENF 1381_ ASKND 1386_ ESQEN 1391_ IKELQ 1396_ LPLSY 1401_ YYIES 1406_ SHNTY 1411_ LTGHQ 1416_ LKGES 1421_ SVELY 1426_ SQVLL 1431_ QGCRS 1436_ VELDC 1441_ WDGDD 1446_ GMPII 1451_ YHGHT 1456_ LTTKI 1461_ PFKEV 1466_ VEAID 1471_ RSAFI 1476_ NSDLP 1481_ IIISI 1486_ ENHCS 1491_ LPQQR 1496_ KMAEI 1501_ FKTVF 1506_ GEKLV 1511_ TKFLF 1516_ ETDFS 1521_ DDPML 1526_ PSPDQ 1531_ LRKKV 1536_ LLKNK 1541_ KLKAH 1546_ QTPVD 1551_ ILKQK 1556_ AHQLA 1561_ SMQVQ 1566_ AYNGG 1571_ NANPR 1576_ PANNE 1581_ EEEDE 1586_ EDEYD 1591_ YDYES 1596_ LSDDN 1601_ ILEDR 1606_ PENKS 1611_ CNDKL 1616_ QFEYN 1621_ EEIPK 1626_ RIKKA 1631_ DNSAC 1636_ NKGKV 1641_ YDMEL 1646_ GEEFY 1651_ LDQNK 1656_ KESRQ 1661_ IAPEL 1666_ SDLVI 1671_ YCQAV 1676_ KFPGL 1681_ STLNA 1686_ SGSSR 1691_ GKERK 1696_ SRKSI 1701_ FGNNP 1706_ GRMSP 1711_ GETAS 1716_ FNKTS 1721_ GKSSC 1726_ EGIRQ 1731_ TWEES 1736_ SSPLN 1741_ PTTSL 1746_ SAIIR 1751_ TPKCY 1756_ HISSL 1761_ NENAA 1766_ KRLCR 1771_ RYSQK 1776_ LTQHT 1781_ ACQLL 1786_ RTYPA 1791_ ATRID 1796_ SSNPN 1801_ PLMFW 1806_ LHGIQ 1811_ LVALN 1816_ YQTDD 1821_ LPLHL 1826_ NAAMF 1831_ EANGG 1836_ CGYVL 1841_ KPPVL 1846_ WDKNC 1851_ PMYQK 1856_ FSPLE 1861_ RDLDS 1866_ MDPAV 1871_ YSLTI 1876_ VSGQN 1881_ VCPSN 1886_ SMGSP 1891_ CIEVD 1896_ VLGMP 1901_ LDSCH 1906_ FRTKP 1911_ IHRNT 1916_ LNPMW 1921_ NEQFL 1926_ FHVHF 1931_ EDLVF 1936_ LRFAV 1941_ VENNS 1946_ SAVTA 1951_ QRIIP 1956_ LKALK 1961_ RGYRH 1966_ LQLRN 1971_ LHNEV 1976_ LEISS 1981_ LFINS 1986_ RRMEE 1991_ NSSGN 1996_ TMSAS 2001_ SMFNT 2006_ EERKC 2011_ LQTHR 2016_ VTVHG 2021_ VPGPE 2026_ PFTVF 2031_ TINGG 2036_ TKAKQ 2041_ LLQQI 2046_ LTNEQ 2051_ DIKPV 2056_ TTDYF 2061_ LMEEK 2066_ YFISK 2071_ EKNEC 2076_ RKQPF 2081_ QRAIG 2086_ PEEEI 2091_ MQILS 2096_ SWFPE 2101_ EGYMG 2106_ RIVLK 2111_ TQQEN 2116_ LEEKN 2121_ IVQDD 2126_ KEVIL 2131_ SSEEE 2136_ SFFVQ 2141_ VHDVS 2146_ PEQPR 2151_ TVIKA 2156_ PRVST 2161_ AQDVI 2166_ QQTLC 2171_ KAKYS 2176_ YSILS 2181_ NPNPS 2186_ DYVLL 2191_ EEVVK 2196_ DTTNK 2201_ KTTTP 2206_ KSSQR 2211_ VLLDQ 2216_ ECVFQ 2221_ AQSKW 2226_ KGAGK 2231_ FILKL 2236_ KEQVQ 2241_ ASRED 2246_ KKKGI 2251_ SFASE 2256_ LKKLT 2261_ KSTKQ 2266_ PRGLT 2271_ SPSQL 2276_ LTSES 2281_ IQTKE 2286_ EKPVG 2291_ GLSSS 2296_DTMDY
1: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly (PubMed:29058690)