Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2)
1_MDVTV 6_ SELLE 11_ LFLQS 16_ PLVTW 21_ VKTFG 26_ PFGSG 31_ SQDNL 36_ TMYMD 41_ LVDGI 46_ FLNQI 51_ MLQID 56_ PRPTN 61_ QRINK 66_ HVNND 71_ VNLRI 76_ QNLTI 81_ LVRNI 86_ KTYYQ 91_ EVLQQ 96_ LIVMN 101_ LPNVL 106_ MIGRD 111_ PLSGK 116_ SMEEI 121_ KKVLL 126_ LVLGC 131_ AVQCE 136_ RKEEF 141_ IERIK 146_ QLDIE 151_ TQAGI 156_ VAHIQ 161_ EVTHN 166_ QENVF 171_ DLQWL 176_ ELPDV 181_ APEEL 186_ EALSR 191_ SMVLH 196_ LRRLI 201_ DQRDE 206_ CTELI 211_ VDLTQ 216_ ERDYL 221_ QAQHP 226_ PSPIK 231_ SSSAD 236_ STPSP 241_ TSSLS 246_ SEDKQ 251_ HLAVE 256_ LADTK 261_ ARLRR 266_ VRQEL 271_ EDKTE 276_ QLVDT 281_ RHEVD 286_ QLVLE 291_ LQKVK 296_ QENIQ 301_ LAADA 306_ RSARA 311_ YRDEL 316_ DSLRE 321_ KANRV 326_ ERLEL 331_ ELTRC 336_ KEKLH 341_ DVDFY 346_ KARME 351_ ELRED 356_ NIILI 361_ ETKAM 366_ LEEQL 371_ TAARA 376_ RGDKV 381_ HELEK 386_ ENLQL 391_ KSKLH 396_ DLELD 401_ RDTDK 406_ KRIEE 411_ LLEEN 416_ MVLEI 421_ AQKQS 426_ MNESA 431_ HLGWE 436_ LEQLS 441_ KNADL 446_ SDASR 451_ KSFVF 456_ ELNEC 461_ ASSRI 466_ LKLEK 471_ ENQSL 476_ QSTIQ 481_ GLRDA 486_ SLVLE 491_ ESGLK 496_ CGELE 501_ KENHQ 506_ LSKKI 511_ EKLQT 516_ QLERE 521_ KQSNQ 526_ DLETL 531_ SEELI 536_ REKEQ 541_ LQSDM 546_ ETLKA 551_ DKARQ 556_ IKDLE 561_ QEKDH 566_ LNRAM 571_ WSLRE 576_ RSQVS 581_ SEARM 586_ KDVEK 591_ ENKAL 596_ HQTVT 601_ EANGK 606_ LSQLE 611_ FEKRQ 616_ LHRDL 621_ EQAKE 626_ KGERA 631_ EKLER 636_ ELQRL 641_ QEENG 646_ RLARK 651_ VTSLE 656_ TATEK 661_ VEALE 666_ HESQG 671_ LQLEN 676_ RTLRK 681_ SLDTL 686_ QNVSL 691_ QLEGL 696_ ERDNK 701_ QLDAE 706_ NLELR 711_ RLVET 716_ MRFTS 721_ TKLAQ 726_ MEREN 731_ QQLER 736_ EKEEL 741_ RKNVD 746_ LLKAL 751_ GKKSE 756_ RLELS 761_ YQSVS 766_ AENLR 771_ LQQSL 776_ ESSSH 781_ KTQTL 786_ ESELG 791_ ELEAE 796_ RQALR 801_ RDLEA 806_ LRLAN 811_ AQLEG 816_ AEKDR 821_ KALEQ 826_ EVAQL 831_ EKDKK 836_ LLEKE 841_ AKRLW 846_ QQVEL 851_ KDAVL 856_ DDSTA 861_ KLSAV 866_ EKESR 871_ ALDKE 876_ LARCR 881_ DAAGK 886_ LKELE 891_ KDNRD 896_ LTKQV 901_ TVHAR 906_ TLTTL 911_ REDLV 916_ LEKLK 921_ SQQLS 926_ SELDK 931_ LSQEL 936_ EKVGL 941_ NRELL 946_ LQEDD 951_ SGSDT 956_ KYKIL 961_ EGRNE 966_ SALKT 971_ TLAMK 976_ EEKIV 981_ LLEAQ 986_ MEEKA 991_ SLNRQ 996_ LESEL 1001_ QMLKK 1006_ ECETL 1011_ RQNQG 1016_ EGQHL 1021_ QNSFK 1026_ HPAGK 1031_ TAASH 1036_ QGKEA 1041_ WGPGH 1046_ KEATM 1051_ ELLRV 1056_ KDRAI 1061_ ELERN 1066_ NAALQ 1071_ AEKQL 1076_ LKEQL 1081_ QHLET 1086_ QNVTF 1091_ SSQIL 1096_ TLQKQ 1101_ SAFLQ 1106_ EHNTT 1111_ LQTQT 1116_ AKLQV 1121_ ENSTL 1126_ SSQSA 1131_ ALTAQ 1136_ YTLLQ 1141_ NHHTA 1146_ KETEN 1151_ ESLQR 1156_ QQEQL 1161_ TAAYE 1166_ ALLQD 1171_ HEHLG 1176_ TLHER 1181_ QSAEY 1186_ EALIR 1191_ QHSCL 1196_ KTLHR 1201_ NLELE 1206_ HKELG 1211_ ERHGD 1216_ MLKRK 1221_ AELEE 1226_ REKVL 1231_ TTERE 1236_ ALQQE 1241_ QRTNA 1246_ LAMGE 1251_ NQRLR 1256_ GELDR 1261_ VNFLH 1266_ HQLKG 1271_ EYEEL 1276_ HAHTK 1281_ ELKTS 1286_ LNNAQ 1291_ LELNR 1296_ WQARF 1301_ DELKE 1306_ QHQTM 1311_ DISLT 1316_ KLDNH 1321_ CELLS 1326_ RLKGN 1331_ LEEEN 1336_ HHLLS 1341_ QIQLL 1346_ SQQNQ 1351_ MLLEQ 1356_ NMENK 1361_ EQYHE 1366_ EQKQY 1371_ IDKLN 1376_ ALRRH 1381_ KEKLE 1386_ EKIMD 1391_ QYKFY 1396_ DPPPK 1401_ KKNHW 1406_ IGAKA 1411_ LVKLI 1416_ KPKKE 1421_ GSRER 1426_ LKSTV 1431_ DSPPW 1436_ QLESS 1441_ DPASP 1446_ AASQP 1451_ LRSQA 1456_ ENPDT 1461_ PALGS 1466_ NCAEE 1471_ RDAHN 1476_ GSVGK 1481_ GPGDL 1486_ KPKRG 1491_ SPHRG 1496_ SLDRT 1501_ DASTD 1506_ LAMRS 1511_ WPSEL 1516_ GSRTC 1521_ STSAT 1526_ TTAPS 1531_ NSTPI 1536_ ARHPG 1541_ RTKGY 1546_ NSDDN 1551_ LCEPS 1556_ LEFEV 1561_ PNHRQ 1566_ YVSRP 1571_ SSLES 1576_ SRNTS 1581_ SNSSP 1586_ LNLKG 1591_ SSEQL 1596_ HGRSE 1601_ SFSSE 1606_ DLIPS 1611_ RDLAT 1616_ LPREA 1621_ STPGR 1626_ NALGR 1631_ HEYPL 1636_ PRNGP 1641_ LPQEG 1646_ AQKRG 1651_ TAPPY 1656_ VGVRP 1661_ CSASP 1666_ SSEMV 1671_ TLEEF 1676_ LEESN 1681_ RSSPT 1686_ HDTPS 1691_ CRDDL 1696_ LSDYF 1701_ RKASD 1706_ PPAIG 1711_ GQPGP 1716_ PAKKE 1721_ GAKMP 1726_ TNFVA 1731_ PTVKM 1736_ AAPTS 1741_ EGRPL 1746_ KPGQY 1751_ VKPNF 1756_ RLTEA 1761_ EAPPS 1766_ VAPRQ 1771_ AQPPQ 1776_ SLSLG 1781_ RPRQA 1786_ PVPPA 1791_ SHAPA 1796_ SRSAS 1801_ LSRAF 1806_ SLASA 1811_ DLLRA 1816_ SGPEA 1821_ CKQES 1826_ PQKLG 1831_ APEAL 1836_ GGRET 1841_ GSHTL 1846_ QSPAP 1851_ PSSHS 1856_ LARER 1861_ TPLVG 1866_ KAGSS 1871_ CQGPG 1876_ PRSRP 1881_ LDTRR 1886_ FSLAP 1891_ PKEER 1896_ LAPLH 1901_ QSATA 1906_ PAIAT 1911_ AGAGA 1916_ AAAGS 1921_ GSNSQ 1926_ LLHFS 1931_ PAAAP 1936_ AARTK 1941_ PKAPP 1946_ RSGEV 1951_ ATITP 1956_ VRAGL 1961_ SLSEG 1966_ DGVPG 1971_ QGCSE 1976_ GLPAK 1981_ SPGRS 1986_ PDLAP 1991_ HLGRA 1996_ LEDCS 2001_ RGSVS 2006_ KSSPA 2011_ SPEPG 2016_ GDPQT 2021_VWYEY
1: Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426)