Stromal interaction molecule 2
1_MLVLG 6_ LLVAG 11_ AADGC 16_ ELVPR 21_ HLRGR 26_ RATGS 31_ AATAA 36_ SSPAA 41_ AAGDS 46_ PALMT 51_ DPCMS 56_ LSPPC 61_ FTEED 66_ RFSLE 71_ ALQTI 76_ HKQMD 81_ DDKDG 86_ GIEVE 91_ ESDEF 96_ IREDM 101_ KYKDA 106_ TNKHS 111_ HLHRE 116_ DKHIT 121_ IEDLW 126_ KRWKT 131_ SEVHN 136_ WTLED 141_ TLQWL 146_ IEFVE 151_ LPQYE 156_ KNFRD 161_ NNVKG 166_ TTLPR 171_ IAVHE 176_ PSFMI 181_ SQLKI 186_ SDRSH 191_ RQKLQ 196_ LKALD 201_ VVLFG 206_ PLTRP 211_ PHNWM 216_ KDFIL 221_ TVSIV 226_ IGVGG 231_ CWFAY 236_ TQNKT 241_ SKEHV 246_ AKMMK 251_ DLESL 256_ QTAEQ 261_ SLMDL 266_ QERLE 271_ KAQEE 276_ NRNVA 281_ VEKQN 286_ LERKM 291_ MDEIN 296_ YAKEE 301_ ACRLR 306_ ELREG 311_ AECEL 316_ SRRQY 321_ AEQEL 326_ EQVRM 331_ ALKKA 336_ EKEFE 341_ LRSSW 346_ SVPDA 351_ LQKWL 356_ QLTHE 361_ VEVQY 366_ YNIKR 371_ QNAEM 376_ QLAIA 381_ KDEAE 386_ KIKKK 391_ RSTVF 396_ GTLHV 401_ AHSSS 406_ LDEVD 411_ HKILE 416_ AKKAL 421_ SELTT 426_ CLRER 431_ LFRWQ 436_ QIEKI 441_ CGFQI 446_ AHNSG 451_ LPSLT 456_ SSLYS 461_ DHSWV 466_ VMPRV 471_ SIPPY 476_ PIAGG 481_ VDDLD 486_ EDTPP 491_ IVSQF 496_ PGTMA 501_ KPPGS 506_ LARSS 511_ SLCRS 516_ RRSIV 521_ PSSPQ 526_ PQRAQ 531_ LAPHA 536_ PHPSH 541_ PRHPH 546_ HPQHT 551_ PHSLP 556_ SPDPD 561_ ILSVS 566_ SCPAL 571_ YRNEE 576_ EEEAI 581_ YFSAE 586_ KQWEV 591_ PDTAS 596_ ECDSL 601_ NSSIG 606_ RKQSP 611_ PLSLE 616_ IYQTL 621_ SPRKI 626_ SRDEV 631_ SLEDS 636_ SRGDS 641_ PVTVD 646_ VSWGS 651_ PDCVG 656_ LTETK 661_ SMIFS 666_ PASKV 671_ YNGIL 676_ EKSCS 681_ MNQLS 686_ SGIPV 691_ PKPRH 696_ TSCSS 701_ AGNDS 706_ KPVQE 711_ APSVA 716_ RISSI 721_ PHDLC 726_ HNGEK 731_ SKKPS 736_ KIKSL 741_FKKKS
1: Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx