Vacuolar protein sorting-associated protein 18 homolog (hVPS18)
1_MASIL 6_ DEYEN 11_ SLSRS 16_ AVLQP 21_ GCPSV 26_ GIPHS 31_ GYVNA 36_ QLEKE 41_ VPIFT 46_ KQRID 51_ FTPSE 56_ RITSL 61_ VVSSN 66_ QLCMS 71_ LGKDT 76_ LLRID 81_ LGKAN 86_ EPNHV 91_ ELGRK 96_ DDAKV 101_ HKMFL 106_ DHTGS 111_ HLLIA 116_ LSSTE 121_ VLYVN 126_ RNGQK 131_ VRPLA 136_ RWKGQ 141_ LVESV 146_ GWNKA 151_ LGTES 156_ STGPI 161_ LVGTA 166_ QGHIF 171_ EAELS 176_ ASEGG 181_ LFGPA 186_ PDLYF 191_ RPLYV 196_ LNEEG 201_ GPAPV 206_ CSLEA 211_ ERGPD 216_ GRSFV 221_ IATTR 226_ QRLFQ 231_ FIGRA 236_ AEGAE 241_ AQGFS 246_ GLFAA 251_ YTDHP 256_ PPFRE 261_ FPSNL 266_ GYSEL 271_ AFYTP 276_ KLRSA 281_ PRAFA 286_ WMMGD 291_ GVLYG 296_ ALDCG 301_ RPDSL 306_ LSEER 311_ VWEYP 316_ EGVGP 321_ GASPP 326_ LAIVL 331_ TQFHF 336_ LLLLA 341_ DRVEA 346_ VCTLT 351_ GQVVL 356_ RDHFL 361_ EKFGP 366_ LKHMV 371_ KDSST 376_ GQLWA 381_ YTERA 386_ VFRYH 391_ VQREA 396_ RDVWR 401_ TYLDM 406_ NRFDL 411_ AKEYC 416_ RERPD 421_ CLDTV 426_ LAREA 431_ DFCFR 436_ QRRYL 441_ ESARC 446_ YALTQ 451_ SYFEE 456_ IALKF 461_ LEARQ 466_ EEALA 471_ EFLQR 476_ KLASL 481_ KPAER 486_ TQATL 491_ LTTWL 496_ TELYL 501_ SRLGA 506_ LQGDP 511_ EALTL 516_ YRETK 521_ ECFRT 526_ FLSSP 531_ RHKEW 536_ LFASR 541_ ASIHE 546_ LLASH 551_ GDTEH 556_ MVYFA 561_ VIMQD 566_ YERVV 571_ AYHCQ 576_ HEAYE 581_ EALAV 586_ LARHR 591_ DPQLF 596_ YKFSP 601_ ILIRH 606_ IPRQL 611_ VDAWI 616_ EMGSR 621_ LDARQ 626_ LIPAL 631_ VNYSQ 636_ GGEVQ 641_ QVSQA 646_ IRYME 651_ FCVNV 656_ LGETE 661_ QAIHN 666_ YLLSL 671_ YARGR 676_ PDSLL 681_ AYLEQ 686_ AGASP 691_ HRVHY 696_ DLKYA 701_ LRLCA 706_ EHGHH 711_ RACVH 716_ VYKVL 721_ ELYEE 726_ AVDLA 731_ LQVDV 736_ DLAKQ 741_ CADLP 746_ EEDEE 751_ LRKKL 756_ WLKIA 761_ RHVVQ 766_ EEEDV 771_ QTAMA 776_ CLASC 781_ PLLKI 786_ EDVLP 791_ FFPDF 796_ VTIDH 801_ FKEAI 806_ CSSLK 811_ AYNHH 816_ IQELQ 821_ REMEE 826_ ATASA 831_ QRIRR 836_ DLQEL 841_ RGRYG 846_ TVEPQ 851_ DKCAT 856_ CDFPL 861_ LNRPF 866_ YLFLC 871_ GHMFH 876_ ADCLL 881_ QAVRP 886_ GLPAY 891_ KQARL 896_ EELQR 901_ KLGAA 906_ PPPAK 911_ GSARA 916_ KEAEG 921_ GAATA 926_ GPSRE 931_ QLKAD 936_ LDELV 941_ AAECV 946_ YCGEL 951_ MIRSI 956_ DRPFI 961_ DPQRY 966_EEEQL
1: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in dendrite development of Pukinje cells (By similarity)