Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5)
1_MNGGK 6_ ECDGG 11_ DKEGG 16_ LPAIQ 21_ VPVGW 26_ QRRVD 31_ QNGVL 36_ YVSPS 41_ GSLLS 46_ CLEQV 51_ KTYLL 56_ TDGTC 61_ KCGLE 66_ CPLIL 71_ PKVFN 76_ FDPGA 81_ AVKQR 86_ TAEDV 91_ KADED 96_ VTKLC 101_ IHKRK 106_ IIAVA 111_ TLHKS 116_ MEAPH 121_ PSLVL 126_ TSPGG 131_ GTNAT 136_ PVVPS 141_ RAATP 146_ RSVRN 151_ KSHEG 156_ ITNSV 161_ MPECK 166_ NPFKL 171_ MIGSS 176_ NAMGR 181_ LYVQE 186_ LPGSQ 191_ QQELH 196_ PVYPR 201_ QRLGS 206_ SEHGQ 211_ KSPFR 216_ GSHGG 221_ LPSPA 226_ SSGSQ 231_ IYGDG 236_ SISPR 241_ TDPLG 246_ SPDVF 251_ TRSNP 256_ GFHGA 261_ PNSSP 266_ IHLNR 271_ TPLSP 276_ PSVML 281_ HGSPV 286_ QSSCA 291_ MAGRT 296_ NIPLS 301_ PTLTT 306_ KSPVM 311_ KKPMC 316_ NFSTN 321_ MEIPR 326_ AMFHH 331_ KPPQG 336_ PPPPP 341_ PPSCA 346_ LQKKP 351_ LTSEK 356_ DPLGI 361_ LDPIP 366_ SKPVN 371_ QNPVI 376_ INPTS 381_ FHSNV 386_ HSQVP 391_ MMNVS 396_ MPPAV 401_ VPLPS 406_ NLPLP 411_ TVKPG 416_ HMNHG 421_ SHVQR 426_ VQHSA 431_ STSLS 436_ PSPVT 441_ SPVHM 446_ MGTGI 451_ GRIEA 456_ SPQRS 461_ RSSST 466_ SSDHG 471_ NFMMP 476_ PVGPQ 481_ ATSSG 486_ IKVPP 491_ RSPRS 496_ TIGSP 501_ RPSMP 506_ SSPST 511_ KSDGH 516_ HQYKD 521_ IPNPL 526_ IAGIS 531_ NVLNT 536_ PSSAA 541_ FPTAS 546_ AGSSS 551_ VKSQP 556_ GLLGM 561_ PLNQI 566_ LNQHN 571_ AASFP 576_ ASSLL 581_ SAAAK 586_ AQLAN 591_ QNKLA 596_ GNNSS 601_ SSSNS 606_ GAVAG 611_ SGNTE 616_ GHSTL 621_ NTMFP 626_ PTANM 631_ LLPTG 636_ EGQSG 641_ RAALR 646_ DKLMS 651_ QQKDA 656_ LRKRK 661_ QPPTT 666_ VLSLL 671_ RQSQM 676_ DSSAV 681_ PKPGP 686_ DLLRK 691_ QGQGS 696_ FPISS 701_ MSQLL 706_ QSMSC 711_ QSSHL 716_ SSNST 721_ PGCGA 726_ SNTAL 731_ PCSAN 736_ QLHFT 741_ DPSMN 746_ SSVLQ 751_ NIPLR 756_ GEAVH 761_ CHNAN 766_ TNFVH 771_ SNSPV 776_ PNHHL 781_ AGLIN 786_ QIQAS 791_ GNCGM 796_ LSQSG 801_ MALGN 806_ SLHPN 811_ PPQSR 816_ ISTSS 821_ TPVIP 826_ NSIVS 831_ SYNQT 836_ SSEAG 841_ GSGPS 846_ SSIAI 851_ AGTNH 856_ PAITK 861_ TTSVL 866_ QDGVI 871_ VTTAA 876_ GNPLQ 881_ SQLPI 886_ GSDFP 891_ FVGQE 896_ HALHF 901_ PSNST 906_ SNNHL 911_ PHPLN 916_ PSLLS 921_ SLPIS 926_ LPVNQ 931_ QHLLN 936_ QNLLN 941_ ILQPS 946_ AGEGD 951_ MSSIN 956_ NTLSN 961_ HQLTH 966_ LQSLL 971_ NNNQM 976_ FPPNQ 981_ QQQQL 986_ LQGYQ 991_ NLQAF 996_ QGQST 1001_ IPCPA 1006_ NNNPM 1011_ ACLFQ 1016_ NFQVR 1021_ MQEDA 1026_ ALLNK 1031_ RISTQ 1036_ PGLTA 1041_ LPENP 1046_ NTTLP 1051_ PFQDT 1056_ PCELQ 1061_ PRIDP 1066_ SLGQQ 1071_ VKDGL 1076_ VVGGP 1081_ GDASV 1086_ DAIYK 1091_ AVVDA 1096_ ASKGM 1101_ QVVIT 1106_ TAVNS 1111_ TTQIS 1116_ PIPAL 1121_ SAMSA 1126_ FTASI 1131_ GDPLN 1136_ LSSAV 1141_ SAVIH 1146_ GRNMG 1151_ GVDHD 1156_ GRLRN 1161_ SRGAR 1166_ LPKNL 1171_ DHGKN 1176_ VNEGD 1181_ GFEYF 1186_ KSASC 1191_ HTSKK 1196_ QWDGE 1201_ QSPRG 1206_ ERNRW 1211_ KYEEF 1216_ LDHPG 1221_ HIHSS 1226_ PCHER 1231_ PNNVS 1236_ TLPFL 1241_ PGEQH 1246_ PILLP 1251_ PRNCP 1256_ GDKIL 1261_ EENFR 1266_ YNNYK 1271_ RTMMS 1276_ FKERL 1281_ ENTVE 1286_ RCAHI 1291_ NGNRP 1296_ RQSRG 1301_ FGELL 1306_ STAKQ 1311_ DLVLE 1316_ EQSPS 1321_ SSNSL 1326_ ENSLV 1331_ KDYIH 1336_ YNGDF 1341_ NAKSV 1346_ NGCVP 1351_ SPSDA 1356_ KSISS 1361_ EDDLR 1366_ NPDSP 1371_ SSNEL 1376_ IHYRP 1381_ RTFNV 1386_ GDLVW 1391_ GQIKG 1396_ LTSWP 1401_ GKLVR 1406_ EDDVH 1411_ NSCQQ 1416_ SPEEG 1421_ KVEPE 1426_ KLKTL 1431_ TEGLE 1436_ AYSRV 1441_ RKRNR 1446_ KSGKL 1451_ NNHLE 1456_ AAIHE 1461_ AMSEL 1466_ DKMSG 1471_ TVHQI 1476_ PQGDR 1481_ QMRPP 1486_KPKRR
1: Non-catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:24634419). Important for stability of PR-DUB components and stimulating its ubiquitinase activity (PubMed:36180891). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in cell growth and survivability (PubMed:36180891). MBD5 and MBD6 containing complexes associate with distinct chromatin regions enriched in genes involved in different pathways (PubMed:36180891). Heterochromatin recruitment is not mediated by DNA methylation (PubMed:20700456). The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:36180891)