Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36)
1_MPIVD 6_ KLKEA 11_ LKPGR 16_ KDSAD 21_ DGELG 26_ KLLAS 31_ SAKKV 36_ LLQKI 41_ EFEPA 46_ SKSFS 51_ YQLEA 56_ LKSKY 61_ VLLNP 66_ KTEGA 71_ SRHKS 76_ GDDPP 81_ ARRQG 86_ SEHTY 91_ ESCGD 96_ GVPAP 101_ QKVLF 106_ PTERL 111_ SLRWE 116_ RVFRV 121_ GAGLH 126_ NLGNT 131_ CFLNA 136_ TIQCL 141_ TYTPP 146_ LANYL 151_ LSKEH 156_ ARSCH 161_ QGSFC 166_ MLCVM 171_ QNHIV 176_ QAFAN 181_ SGNAI 186_ KPVSF 191_ IRDLK 196_ KIARH 201_ FRFGN 206_ QEDAH 211_ EFLRY 216_ TIDAM 221_ QKACL 226_ NGCAK 231_ LDRQT 236_ QATTL 241_ VHQIF 246_ GGYLR 251_ SRVKC 256_ SVCKS 261_ VSDTY 266_ DPYLD 271_ VALEI 276_ RQAAN 281_ IVRAL 286_ ELFVK 291_ ADVLS 296_ GENAY 301_ MCAKC 306_ KKKVP 311_ ASKRF 316_ TIHRT 321_ SNVLT 326_ LSLKR 331_ FANFS 336_ GGKIT 341_ KDVGY 346_ PEFLN 351_ IRPYM 356_ SQNNG 361_ DPVMY 366_ GLYAV 371_ LVHSG 376_ YSCHA 381_ GHYYC 386_ YVKAS 391_ NGQWY 396_ QMNDS 401_ LVHSS 406_ NVKVV 411_ LNQQA 416_ YVLFY 421_ LRIPG 426_ SKKSP 431_ EGLIS 436_ RTGSS 441_ SLPGR 446_ PSVIP 451_ DHSKK 456_ NIGNG 461_ IISSP 466_ LTGKR 471_ QDSGT 476_ MKKPH 481_ TTEEI 486_ GVPIS 491_ RNGST 496_ LGLKS 501_ QNGCI 506_ PPKLP 511_ SGSPS 516_ PKLSQ 521_ TPTHM 526_ PTILD 531_ DPGKK 536_ VKKPA 541_ PPQHF 546_ SPRTA 551_ QGLPG 556_ TSNSN 561_ SSRSG 566_ SQRQG 571_ SWDSR 576_ DVVLS 581_ TSPKL 586_ LATAT 591_ ANGHG 596_ LKGND 601_ ESAGL 606_ DRRGS 611_ SSSSP 616_ EHSAS 621_ SDSTK 626_ APQTP 631_ RSGAA 636_ HLCDS 641_ QETNC 646_ STAGH 651_ SKTPP 656_ SGADS 661_ KTVKL 666_ KSPVL 671_ SNTTT 676_ EPAST 681_ MSPPP 686_ AKKLA 691_ LSAKK 696_ ASTLW 701_ RATGN 706_ DLRPP 711_ PPSPS 716_ SDLTH 721_ PMKTS 726_ HPVVA 731_ STWPV 736_ HRARA 741_ VSPAP 746_ QSSSR 751_ LQPPF 756_ SPHPT 761_ LLSST 766_ PKPPG 771_ TSEPR 776_ SCSSI 781_ STALP 786_ QVNED 791_ LVSLP 796_ HQLPE 801_ ASEPP 806_ QSPSE 811_ KRKKT 816_ FVGEP 821_ QRLGS 826_ ETRLP 831_ QHIRE 836_ ATAAP 841_ HGKRK 846_ RKKKK 851_ RPEDT 856_ AASAL 861_ QEGQT 866_ QRQPG 871_ SPMYR 876_ REGQA 881_ QLPAV 886_ RRQED 891_ GTQPQ 896_ VNGQQ 901_ VGCVT 906_ DGHHA 911_ SSRKR 916_ RRKGA 921_ EGLGE 926_ EGGLH 931_ QDPLR 936_ HSCSP 941_ MGDGD 946_ PEAME 951_ ESPRK 956_ KKKKK 961_ RKQET 966_ QRAVE 971_ EDGHL 976_ KCPRS 981_ AKPQD 986_ AVVPE 991_ SSSCA 996_ PSANG 1001_ WCPGD 1006_ RMGLS 1011_ QAPPV 1016_ SWNGE 1021_ RESDV 1026_ VQELL 1031_ KYSSD 1036_ KAYGR 1041_ KVLTW 1046_ DGKMS 1051_ AVSQD 1056_ AIEDS 1061_ RQART 1066_ ETVVD 1071_ DWDEE 1076_ FDRGK 1081_ EKKIK 1086_ KFKRE 1091_ KRRNF 1096_ NAFQK 1101_ LQTRR 1106_ NFWSV 1111_ THPAK 1116_AASLS
1: Deubiquitinase essential for the regulation of nucleolar structure and function (PubMed:19208757, PubMed:22902402, PubMed:29273634). Required for cell and organism viability (PubMed:19208757, PubMed:22902402, PubMed:29273634). Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:19208757, PubMed:22902402, PubMed:29273634, PubMed:36912080). Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex (PubMed:25775507). In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338). Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071). Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Promotes CEP63 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability (PubMed:35989368). Acts as a SUMO ligase to promote EXOSC10 sumoylation critical for the nucleolar RNA exosome function in rRNA processing (PubMed:36912080). Binds to pre-rRNAs (PubMed:36912080)