Folliculin-interacting protein 2 (FNIP1-like protein) (O6-methylguanine-induced apoptosis 1 protein)
1_MAPTL 6_ LQKLF 11_ NKRGS 16_ SGSSA 21_ AASAQ 26_ GRAPK 31_ EGPAF 36_ SWSCS 41_ EFDLN 46_ EIRLI 51_ VYQDC 56_ DRRGR 61_ QVLFD 66_ SKAVQ 71_ KIEEV 76_ TAQKT 81_ EDVPI 86_ KISAK 91_ CCQGS 96_ SSVSS 101_ SSSSS 106_ ISSHS 111_ SSGGS 116_ SHHAK 121_ EQLPK 126_ YQYTR 131_ PASDV 136_ NMLGE 141_ MMFGS 146_ VAMSY 151_ KGSTL 156_ KIHYI 161_ RSPPQ 166_ LMISK 171_ VFSAR 176_ MGSFC 181_ GSTNN 186_ LQDSF 191_ EYINQ 196_ DPNLG 201_ KLNTN 206_ QNSLG 211_ PCRTG 216_ SNLAH 221_ STPVD 226_ MPSRG 231_ QNEDR 236_ DSGIA 241_ RSASL 246_ SSLLI 251_ TPFPS 256_ PSSST 261_ SSSSS 266_ YQRRW 271_ LRSQT 276_ TSLEN 281_ GIIPR 286_ RSTDE 291_ TFSLA 296_ EETCS 301_ SNPAM 306_ VRRKK 311_ IAISI 316_ IFSLC 321_ EKEEA 326_ QRNFQ 331_ DFFFS 336_ HFPLF 341_ ESHMN 346_ RLKSA 351_ IEKAM 356_ ISCRK 361_ IAESS 366_ LRVQF 371_ YVSRL 376_ MEALG 381_ EFRGT 386_ IWNLY 391_ SVPRI 396_ AEPVW 401_ LTMMS 406_ GTLEK 411_ NQLCQ 416_ RFLKE 421_ FTLLI 426_ EQINK 431_ NQFFA 436_ ALLTA 441_ VLTYH 446_ LAWVP 451_ TVMPV 456_ DHPPI 461_ KAFSE 466_ KRTSQ 471_ SVNML 476_ AKTHP 481_ YNPLW 486_ AQLGD 491_ LYGAI 496_ GSPVR 501_ LTRTV 506_ VVGKQ 511_ KDLVQ 516_ RILYV 521_ LTYFL 526_ RCSEL 531_ QENQL 536_ TWSGN 541_ HGEGD 546_ QVLNG 551_ SKIIT 556_ ALEKG 561_ EVEES 566_ EYVVI 571_ TVRNE 576_ PALVP 581_ PILPP 586_ TAAER 591_ HNPWP 596_ TGFPE 601_ CPEGT 606_ DSRDL 611_ GLKPD 616_ KEANR 621_ RPEQG 626_ SEACS 631_ AGCLG 636_ PASDA 641_ SWKPQ 646_ NAFCG 651_ DEKNK 656_ EAPQD 661_ GSSRL 666_ PSCEV 671_ LGAGM 676_ KMDQQ 681_ AVCEL 686_ LKVEM 691_ PTRLP 696_ DRSVA 701_ WPCPD 706_ RHLRE 711_ KPSLE 716_ KVTFQ 721_ IGSFA 726_ SPESD 731_ FESRM 736_ KKMEE 741_ RVKAC 746_ GPSLE 751_ ASEAA 756_ DVAQD 761_ PQVSR 766_ SPFKP 771_ GFQEN 776_ VCCPQ 781_ NRLSE 786_ GDEGE 791_ SDKGF 796_ AEDRG 801_ SRNDM 806_ AADIA 811_ GQLSH 816_ AADLG 821_ TASHG 826_ AGGTG 831_ GRRLE 836_ ATRGL 841_ YVKAA 846_ EGPVL 851_ EPVAP 856_ RCVQR 861_ GPGLV 866_ AGANI 871_ PCGDD 876_ NKKAN 881_ FRTEG 886_ DIPRN 891_ ESSDS 896_ ALGDS 901_ DDEAC 906_ ASAML 911_ DLGHG 916_ GDRTG 921_ GSLEV 926_ ELPLP 931_ RSQSI 936_ STQNV 941_ RNFGR 946_ SLLAG 951_ YCPTY 956_ MPDLV 961_ LHGTG 966_ SDEKL 971_ KQCLV 976_ ADLVH 981_ TVHHP 986_ VLDEP 991_ IAEAV 996_ CIIAD 1001_ TDKWS 1006_ VQVAT 1011_ SQRKV 1016_ TDNMK 1021_ LGQDV 1026_ LVSSQ 1031_ VSSLL 1036_ QSILQ 1041_ LYKLH 1046_ LPADF 1051_ CIMHL 1056_ EDRLQ 1061_ EMYLK 1066_ SKMLS 1071_ EYLRG 1076_ HTRVH 1081_ VKELG 1086_ VVLGI 1091_ ESNDL 1096_ PLLTA 1101_ IASTH 1106_SPYVA
1: Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:18663353, PubMed:31672913, PubMed:36103527). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases, leading to activation of the non-canonical mTORC1 signaling (By similarity). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (PubMed:31672913, PubMed:36103527). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent inactivation of TFEB and TFE3 (PubMed:31672913). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:18403135). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:18403135). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:18403135). May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions (By similarity)