BRCA2 and CDKN1A-interacting protein (P21- and CDK-associated protein 1) (Protein TOK-1)
1_MASRS 6_ KRRAV 11_ ESGVP 16_ QPPDP 21_ PVQRD 26_ EEEEK 31_ EVENE 36_ DEDDD 41_ DSDKE 46_ KDEED 51_ EVIDE 56_ EVNIE 61_ FEAYS 66_ LSDND 71_ YDGIK 76_ KLLQQ 81_ LFLKA 86_ PVNTA 91_ ELTDL 96_ LIQQN 101_ HIGSV 106_ IKQTD 111_ VSEDS 116_ NDDMD 121_ EDEVF 126_ GFISL 131_ LNLTE 136_ RKGTQ 141_ CVEQI 146_ QELVL 151_ RFCEK 156_ NCEKS 161_ MVEQL 166_ DKFLN 171_ DTTKP 176_ VGLLL 181_ SERFI 186_ NVPPQ 191_ IALPM 196_ YQQLQ 201_ KELAG 206_ AHRTN 211_ KPCGK 216_ CYFYL 221_ LISKT 226_ FVEAG 231_ KNNSK 236_ KKPSN 241_ KKKAA 246_ LMFAN 251_ AEEEF 256_ FYEKA 261_ ILKFN 266_ YSVQE 271_ ESDTC 276_ LGGKW 281_ SFDDV 286_ PMTPL 291_ RTVML 296_ IPGDK 301_ MNEIM 306_DKLKE
1: During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole (PubMed:28394342). Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta (PubMed:28394342). May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ)