Serine/threonine-protein kinase 26 (EC 2.7.11.1) (MST3 and SOK1-related kinase) (Mammalian STE20-like protein kinase 4) (MST-4) (STE20-like kinase MST4) (Serine/threonine-protein kinase MASK)
1_MAHSP 6_ VAVQV 11_ PGMQN 16_ NIADP 21_ EELFT 26_ KLERI 31_ GKGSF 36_ GEVFK 41_ GIDNR 46_ TQQVV 51_ AIKII 56_ DLEEA 61_ EDEIE 66_ DIQQE 71_ ITVLS 76_ QCDSS 81_ YVTKY 86_ YGSYL 91_ KGSKL 96_ WIIME 101_ YLGGG 106_ SALDL 111_ LRAGP 116_ FDEFQ 121_ IATML 126_ KEILK 131_ GLDYL 136_ HSEKK 141_ IHRDI 146_ KAANV 151_ LLSEQ 156_ GDVKL 161_ ADFGV 166_ AGQLT 171_ DTQIK 176_ RNTFV 181_ GTPFW 186_ MAPEV 191_ IQQSA 196_ YDSKA 201_ DIWSL 206_ GITAI 211_ ELAKG 216_ EPPNS 221_ DMHPM 226_ RVLFL 231_ IPKNN 236_ PPTLV 241_ GDFTK 246_ SFKEF 251_ IDACL 256_ NKDPS 261_ FRPTA 266_ KELLK 271_ HKFIV 276_ KNSKK 281_ TSYLT 286_ ELIDR 291_ FKRWK 296_ AEGHS 301_ DDESD 306_ SEGSD 311_ SESTS 316_ RENNT 321_ HPEWS 326_ FTTVR 331_ KKPDP 336_ KKVQN 341_ GAEQD 346_ LVQTL 351_ SCLSM 356_ IITPA 361_ FAELK 366_ QQDEN 371_ NASRN 376_ QAIEE 381_ LEKSI 386_ AVAEA 391_ ACPGI 396_ TDKMV 401_ KKLIE 406_ KFQKC 411_SADES
1: Serine/threonine-protein kinase that acts as a mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Phosphorylates ATG4B at 'Ser-383', thereby increasing autophagic flux (PubMed:29232556). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753)