Coatomer subunit zeta-2 (Zeta-2-coat protein) (Zeta-2 COP)
1_MQRPE 6_ AWPRP 11_ HPGEG 16_ AAAAQ 21_ AGGPA 26_ PPARA 31_ GEPSG 36_ LRLQE 41_ PSLYT 46_ IKAVF 51_ ILDND 56_ GRRLL 61_ AKYYD 66_ DTFPS 71_ MKEQM 76_ VFEKN 81_ VFNKT 86_ SRTES 91_ EIAFF 96_ GGMTI 101_ VYKNS 106_ IDLFL 111_ YVVGS 116_ SYENE 121_ LMLMS 126_ VLTCL 131_ FESLN 136_ HMLRK 141_ NVEKR 146_ WLLEN 151_ MDGAF 156_ LVLDE 161_ IVDGG 166_ VILES 171_ DPQQV 176_ IQKVN 181_ FRADD 186_ GGLTE 191_ QSVAQ 196_ VLQSA 201_KEQIK
1: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex