Inhibitor of Bruton tyrosine kinase (IBtk)
1_MSSPM 6_ PDCTS 11_ KCRSL 16_ KHALD 21_ VLSVV 26_ TKGSE 31_ NQIKA 36_ FLSSH 41_ CYNAA 46_ TIKDV 51_ FGRNA 56_ LHLVS 61_ SCGKK 66_ GVLDW 71_ LIQKG 76_ VDLLV 81_ KDKES 86_ GWTAL 91_ HRSIF 96_ YGHID 101_ CVWSL 106_ LKHGV 111_ SLYIQ 116_ DKEGL 121_ SALDL 126_ VMKDR 131_ PTHVV 136_ FKNTD 141_ PTDVY 146_ TWGDN 151_ TNFTL 156_ GHGSQ 161_ NSKHH 166_ PELVD 171_ LFSRS 176_ GIYIK 181_ QVVLC 186_ KFHSV 191_ FLSQK 196_ GQVYT 201_ CGHGP 206_ GGRLG 211_ HGDEQ 216_ TCLVP 221_ RLVEG 226_ LNGHN 231_ CSQVA 236_ AAKDH 241_ TVVLT 246_ EDGCV 251_ YTFGL 256_ NIFHQ 261_ LGIIP 266_ PPSSC 271_ NVPRQ 276_ IQAKY 281_ LKGRT 286_ IIGVA 291_ AGRFH 296_ TVLWT 301_ REAVY 306_ TMGLN 311_ GGQLG 316_ CLLDP 321_ NGEKC 326_ VTAPR 331_ QVSAL 336_ HHKDI 341_ ALSLV 346_ AASDG 351_ ATVCV 356_ TTRGD 361_ IYLLA 366_ DYQCK 371_ KMASK 376_ QLNLK 381_ KVLVS 386_ GGHME 391_ YKVDP 396_ EHLKE 401_ NGGQK 406_ ICILA 411_ MDGAG 416_ RVFCW 421_ RSVNS 426_ SLKQC 431_ RWAYP 436_ RQVFI 441_ SDIAL 446_ NRNEI 451_ LFVTQ 456_ DGEGF 461_ RGRWF 466_ EEKRK 471_ SSEKK 476_ EILSN 481_ LHNSS 486_ SDVSY 491_ VSDIN 496_ SVYER 501_ IRLEK 506_ LTFAH 511_ RAVSV 516_ STDPS 521_ GCNFA 526_ ILQSD 531_ PKTSL 536_ YEIPA 541_ VSSSS 546_ FFEEF 551_ GKLLR 556_ EADEM 561_ DSIHD 566_ VTFQV 571_ GNRLF 576_ PAHKY 581_ ILAVH 586_ SDFFQ 591_ KLFLS 596_ DGNTS 601_ EFTDI 606_ YQKDE 611_ DSAGC 616_ HLFVV 621_ EKVHP 626_ DMFEY 631_ LLQFI 636_ YTDTC 641_ DFLTH 646_ GFKPR 651_ IHLNK 656_ NPEEY 661_ QGTLN 666_ SHLNK 671_ VNFHE 676_ DDNQK 681_ SAFEV 686_ YKSNQ 691_ AQTVS 696_ ERQKS 701_ KPKSC 706_ KKGKN 711_ IREDD 716_ PVRML 721_ QTVAK 726_ KFDFS 731_ NLSSR 736_ LDGVR 741_ FENEK 746_ INVIA 751_ KNTGN 756_ KLKLS 761_ QKKCS 766_ FLCDV 771_ TMKSV 776_ DGKEF 781_ PCHKC 786_ VLCAR 791_ LEYFH 796_ SMLSS 801_ SWIEA 806_ SSCAA 811_ LEMPI 816_ HSDIL 821_ KVILD 826_ YLYTD 831_ EAVVI 836_ KESQN 841_ VDFIC 846_ SVLVV 851_ ADQLL 856_ ITRLK 861_ EICEV 866_ ALTEK 871_ LTLKN 876_ AAMLL 881_ EFAAM 886_ YSAKQ 891_ LKLSC 896_ LQFIG 901_ LNMAA 906_ LLEAR 911_ SLDVL 916_ SDGVL 921_ KDLSE 926_ FYRKM 931_ IPAMD 936_ RRVIT 941_ PYQDG 946_ PDISY 951_ LEVED 956_ GDIFL 961_ KEEIN 966_ MEQNH 971_ SETMF 976_ KKAKT 981_ KAKKK 986_ PRKRS 991_ DSSGG 996_ YNLSD 1001_ IIQSP 1006_ SSTGL 1011_ LKSGK 1016_ TNSVE 1021_ SLPEL 1026_ LTSDS 1031_ EGSYA 1036_ GVGSP 1041_ RDLQS 1046_ PDFTT 1051_ GFHSD 1056_ KIEAK 1061_ VKPYV 1066_ NGTSP 1071_ VYSRE 1076_ DLKPW 1081_ EKSPI 1086_ LKISA 1091_ PQPIP 1096_ SNRID 1101_ TTSSA 1106_ SWVAG 1111_ SFSPV 1116_ SPPVV 1121_ DLRTI 1126_ MEIEE 1131_ SRQKC 1136_ GATPK 1141_ SHLGK 1146_ TVSHG 1151_ VKLSQ 1156_ KQRKM 1161_ IALTT 1166_ KENNS 1171_ GMNSM 1176_ ETVLF 1181_ TPSKA 1186_ PKPVN 1191_ AWASS 1196_ LHSVS 1201_ SKSFR 1206_ DFLLE 1211_ EKKSV 1216_ TSHSS 1221_ GDHVK 1226_ KVSFK 1231_ GIENS 1236_ QAPKI 1241_ VRCST 1246_ HGTPG 1251_ PEGNH 1256_ ISDLP 1261_ LLDSP 1266_ NPWLS 1271_ SSVTA 1276_ PSMVA 1281_ PVTFA 1286_ SIVEE 1291_ ELQQE 1296_ AALIR 1301_ SREKP 1306_ LALIQ 1311_ IEEHA 1316_ IQDLL 1321_ VFYEA 1326_ FGNPE 1331_ EFVIV 1336_ ERTPQ 1341_ GPLAV 1346_PMWNK
1: Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription