E3 ubiquitin-protein ligase MARCHF4 (EC 2.3.2.27) (Membrane-associated RING finger protein 4) (Membrane-associated RING-CH protein IV) (MARCH-IV) (RING finger protein 174) (RING-type E3 ubiquitin transferase MARCHF4)
1_MLMPL 6_ CGLLW 11_ WWWCC 16_ CSGWY 21_ CYGLC 26_ APAPQ 31_ MLRHQ 36_ GLLKC 41_ RCRML 46_ FNDLK 51_ VFLLR 56_ RPPQA 61_ PLPMH 66_ GDPQP 71_ PGLAA 76_ NNTLP 81_ ALGAG 86_ GWAGW 91_ RGPRE 96_ VVGRE 101_ PPPVP 106_ PPPPL 111_ PPSSV 116_ EDDWG 121_ GPATE 126_ PPASL 131_ LSSAS 136_ SDDFC 141_ KEKTE 146_ DRYSL 151_ GSSLD 156_ SGMRT 161_ PLCRI 166_ CFQGP 171_ EQGEL 176_ LSPCR 181_ CDGSV 186_ KCTHQ 191_ PCLIK 196_ WISER 201_ GCWSC 206_ ELCYY 211_ KYHVI 216_ AISTK 221_ NPLQW 226_ QAISL 231_ TVIEK 236_ VQVAA 241_ AILGS 246_ LFLIA 251_ SISWL 256_ IWSTF 261_ SPSAR 266_ WQRQD 271_ LLFQI 276_ CYGMY 281_ GFMDV 286_ VCIGL 291_ IIHEG 296_ PSVYR 301_ IFKRW 306_ QAVNQ 311_ QWKVL 316_ NYDKT 321_ KDLED 326_ QKAGG 331_ RTNPR 336_ TSSST 341_ QANIP 346_ SSEEE 351_ TAGTP 356_ APEQG 361_ PAQAA 366_ GHPSG 371_ PLSHH 376_ HCAYT 381_ ILHIL 386_ SHLRP 391_ HEQRS 396_ PPGSS 401_RELVM
1: E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates