Ubiquitin carboxyl-terminal hydrolase 35 (EC 3.4.19.12) (Deubiquitinating enzyme 35) (Ubiquitin thioesterase 35) (Ubiquitin-specific-processing protease 35)
1_MDKIL 6_ EAVVT 11_ SSYPV 16_ SVKQG 21_ LVRRV 26_ LEAAR 31_ QPLER 36_ EQCLA 41_ LLALG 46_ ARLYV 51_ GGAEE 56_ LPRRV 61_ GCQLL 66_ HVAGR 71_ HHPDV 76_ FAEFF 81_ SARRV 86_ LRLLQ 91_ GGAGP 96_ PGPRA 101_ LACVQ 106_ LGLQL 111_ LPEGP 116_ AADEV 121_ FALLR 126_ REVLR 131_ TVCER 136_ PGPAA 141_ CAQVA 146_ RLLAR 151_ HPRCV 156_ PDGPH 161_ RLLFC 166_ QQLVR 171_ CLGRF 176_ RCPAE 181_ GEEGA 186_ VEFLE 191_ QAQQV 196_ SGLLA 201_ QLWRA 206_ QPAAI 211_ LPCLK 216_ ELFAV 221_ ISCAE 226_ EEPPS 231_ SALAS 236_ VVQHL 241_ PLELM 246_ DGVVR 251_ NLSND 256_ DSVTD 261_ SQMLT 266_ AISRM 271_ IDWVS 276_ WPLGK 281_ NIDKW 286_ IIALL 291_ KGLAA 296_ VKKFS 301_ ILIEV 306_ SLTKI 311_ EKVFS 316_ KLLYP 321_ IVRGA 326_ ALSVL 331_ KYMLL 336_ TFQHS 341_ HEAFH 346_ LLLPH 351_ IPPMV 356_ ASLVK 361_ EDSNS 366_ GTSCL 371_ EQLAE 376_ LVHCM 381_ VFRFP 386_ GFPDL 391_ YEPVM 396_ EAIKD 401_ LHVPN 406_ EDRIK 411_ QLLGQ 416_ DAWTS 421_ QKSEL 426_ AGFYP 431_ RLMAK 436_ SDTGK 441_ IGLIN 446_ LGNTC 451_ YVNSI 456_ LQALF 461_ MASDF 466_ RHCVL 471_ RLTEN 476_ NSQPL 481_ MTKLQ 486_ WLFGF 491_ LEHSQ 496_ RPAIS 501_ PENFL 506_ SASWT 511_ PWFSP 516_ GTQQD 521_ CSEYL 526_ KYLLD 531_ RLHEE 536_ EKTGT 541_ RICQK 546_ LKQSS 551_ SPSPP 556_ EEPPA 561_ PSSTS 566_ VEKMF 571_ GGKIV 576_ TRICC 581_ LCCLN 586_ VSSRE 591_ EAFTD 596_ LSLAF 601_ PPPER 606_ CRRRR 611_ LGSVM 616_ RPTED 621_ ITARE 626_ LPPPT 631_ SAQGP 636_ GRVGP 641_ RRQRK 646_ HCITE 651_ DTPPT 656_ SLYIE 661_ GLDSK 666_ EAGGQ 671_ SSQEE 676_ RIERE 681_ EEGKE 686_ ERTEK 691_ EEVGE 696_ EEEST 701_ RGEGE 706_ REKEE 711_ EVEEE 716_ EEKVE 721_ KETEK 726_ EAEQE 731_ KEEDS 736_ LGAGT 741_ HPDAA 746_ IPSGE 751_ RTCGS 756_ EGSRS 761_ VLDLV 766_ NYFLS 771_ PEKLT 776_ AENRY 781_ YCESC 786_ ASLQD 791_ AEKVV 796_ ELSQG 801_ PCYLI 806_ LTLLR 811_ FSFDL 816_ RTMRR 821_ RKILD 826_ DVSIP 831_ LLLRL 836_ PLAGG 841_ RGQAY 846_ DLCSV 851_ VVHSG 856_ VSSES 861_ GHYYC 866_ YAREG 871_ AARPA 876_ ASLGT 881_ ADRPE 886_ PENQW 891_ YLFND 896_ TRVSF 901_ SSFES 906_ VSNVT 911_ SFFPK 916_ DTAYV 921_ LFYRQ 926_ RPREG 931_ PEAEL 936_ GSSRV 941_ RTEPT 946_ LHKDL 951_ MEAIS 956_ KDNIL 961_ YLQEQ 966_ EKEAR 971_ SRAAY 976_ ISALP 981_ TSPHW 986_ GRGFD 991_ EDKDE 996_ DEGSP 1001_ GGCNP 1006_ AGGNG 1011_GDFHR
1: Deubiquitinase that plays a role in different processes including cell cycle regulation, mitophagy or endoplasmic reticulum stress (PubMed:26348204, PubMed:29449677, PubMed:37004621). Inhibits TNFalpha-induced NF-kappa-B activation through stabilizing TNIP2 protein via deubiquitination (PubMed:26348204). Plays an essential role during mitosis by deubiquitinating and thereby regulating the levels of Aurora B/AURKB protein (PubMed:29449677). In addition, regulates the protein levels of other key component of the chromosomal passenger complex (CPC) such as survivin/BIRC5 or Borealin/CDCA8 by enhancing their stability (PubMed:34438346). Regulates the degradation of mitochondria through the process of autophagy termed mitophagy (PubMed:25915564)