eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 4) (GCN2-like protein)
1_MAGGR 6_ GAPGR 11_ GRDEP 16_ PESYP 21_ QRQDH 26_ ELQAL 31_ EAIYG 36_ ADFQD 41_ LRPDA 46_ CGPVK 51_ EPPEI 56_ NLVLY 61_ PQGLT 66_ GEEVY 71_ VKVDL 76_ RVKCP 81_ PTYPD 86_ VVPEI 91_ ELKNA 96_ KGLSN 101_ ESVNL 106_ LKSRL 111_ EELAK 116_ KHCGE 121_ VMIFE 126_ LAYHV 131_ QSFLS 136_ EHNKP 141_ PPKSF 146_ HEEML 151_ ERRAQ 156_ EEQQR 161_ LLEAK 166_ RKEEQ 171_ EQREI 176_ LHEIQ 181_ RRKEE 186_ IKEEK 191_ KRKEM 196_ AKQER 201_ LEIAS 206_ LSNQD 211_ HTSKK 216_ DPGGH 221_ RTAAI 226_ LHGGS 231_ PDFVG 236_ NGKHR 241_ ANSSG 246_ RSRRE 251_ RQYSV 256_ CNSED 261_ SPGSC 266_ EILYF 271_ NMGSP 276_ DQLMV 281_ HKGKC 286_ IGSDE 291_ QLGKL 296_ VYNAL 301_ ETATG 306_ GFVLL 311_ YEWVL 316_ QWQKK 321_ MGPFL 326_ TSQEK 331_ EKIDK 336_ CKKQI 341_ QGTET 346_ EFNSL 351_ VKLSH 356_ PNVVR 361_ YLAMN 366_ LKEQD 371_ DSIVV 376_ DILVE 381_ HISGV 386_ SLAAH 391_ LSHSG 396_ PIPVH 401_ QLRRY 406_ TAQLL 411_ SGLDY 416_ LHSNS 421_ VVHKV 426_ LSASN 431_ VLVDA 436_ EGTVK 441_ ITDYS 446_ ISKRL 451_ ADICK 456_ EDVFE 461_ QTRVR 466_ FSDNA 471_ LPYKT 476_ GKKGD 481_ VWRLG 486_ LLLLS 491_ LSQGQ 496_ ECGEY 501_ PVTIP 506_ SDLPA 511_ DFQDF 516_ LKKCV 521_ CLDDK 526_ ERWSP 531_ QQLLK 536_ HSFIN 541_ PQPKM 546_ PLVEQ 551_ SPEDS 556_ EGQDY 561_ VETVI 566_ PSNRL 571_ PSAAF 576_ FSETQ 581_ RQFSR 586_ YFIEF 591_ EELQL 596_ LGKGA 601_ FGAVI 606_ KVQNK 611_ LDGCC 616_ YAVKR 621_ IPINP 626_ ASRQF 631_ RRIKG 636_ EVTLL 641_ SRLHH 646_ ENIVR 651_ YYNAW 656_ IERHE 661_ RPAGP 666_ GTPPP 671_ DSGPL 676_ AKDDR 681_ AARGQ 686_ PASDT 691_ DGLDS 696_ VEAAA 701_ PPPIL 706_ SSSVE 711_ WSTSG 716_ ERSAS 721_ ARFPA 726_ TGPGS 731_ SDDED 736_ DDEDE 741_ HGGVF 746_ SQSFL 751_ PASDS 756_ ESDII 761_ FDNED 766_ ENSKS 771_ QNQDE 776_ DCNEK 781_ NGCHE 786_ SEPSV 791_ TTEAV 796_ HYLYI 801_ QMEYC 806_ EKSTL 811_ RDTID 816_ QGLYR 821_ DTVRL 826_ WRLFR 831_ EILDG 836_ LAYIH 841_ EKGMI 846_ HRDLK 851_ PVNIF 856_ LDSDD 861_ HVKIG 866_ DFGLA 871_ TDHLA 876_ FSADS 881_ KQDDQ 886_ TGDLI 891_ KSDPS 896_ GHLTG 901_ MVGTA 906_ LYVSP 911_ EVQGS 916_ TKSAY 921_ NQKVD 926_ LFSLG 931_ IIFFE 936_ MSYHP 941_ MVTAS 946_ ERIFV 951_ LNQLR 956_ DPTSP 961_ KFPED 966_ FDDGE 971_ HAKQK 976_ SVISW 981_ LLNHD 986_ PAKRP 991_ TATEL 996_ LKSEL 1001_ LPPPQ 1006_ MEESE 1011_ LHEVL 1016_ HHTLT 1021_ NVDGK 1026_ AYRTM 1031_ MAQIF 1036_ SQRIS 1041_ PAIDY 1046_ TYDSD 1051_ ILKGN 1056_ FSIRT 1061_ AKMQQ 1066_ HVCET 1071_ IIRIF 1076_ KRHGA 1081_ VQLCT 1086_ PLLLP 1091_ RNRQI 1096_ YEHNE 1101_ AALFM 1106_ DHSGM 1111_ LVMLP 1116_ FDLRI 1121_ PFARY 1126_ VARNN 1131_ ILNLK 1136_ RYCIE 1141_ RVFRP 1146_ RKLDR 1151_ FHPKE 1156_ LLECA 1161_ FDIVT 1166_ STTNS 1171_ FLPTA 1176_ EIIYT 1181_ IYEII 1186_ QEFPA 1191_ LQERN 1196_ YSIYL 1201_ NHTML 1206_ LKAIL 1211_ LHCGI 1216_ PEDKL 1221_ SQVYI 1226_ ILYDA 1231_ VTEKL 1236_ TRREV 1241_ EAKFC 1246_ NLSLS 1251_ SNSLC 1256_ RLYKF 1261_ IEQKG 1266_ DLQDL 1271_ MPTIN 1276_ SLIKQ 1281_ KTGIA 1286_ QLVKY 1291_ GLKDL 1296_ EEVVG 1301_ LLKKL 1306_ GIKLQ 1311_ VLINL 1316_ GLVYK 1321_ VQQHN 1326_ GIIFQ 1331_ FVAFI 1336_ KRRQR 1341_ AVPEI 1346_ LAAGG 1351_ RYDLL 1356_ IPQFR 1361_ GPQAL 1366_ GPVPT 1371_ AIGVS 1376_ IAIDK 1381_ ISAAV 1386_ LNMEE 1391_ SVTIS 1396_ SCDLL 1401_ VVSVG 1406_ QMSMS 1411_ RAINL 1416_ TQKLW 1421_ TAGIT 1426_ AEIMY 1431_ DWSQS 1436_ QEELQ 1441_ EYCRH 1446_ HEITY 1451_ VALVS 1456_ DKEGS 1461_ HVKVK 1466_ SFEKE 1471_ RQTEK 1476_ RVLET 1481_ ELVDH 1486_ VLQKL 1491_ RTKVT 1496_ DERNG 1501_ REASD 1506_ NLAVQ 1511_ NLKGS 1516_ FSNAS 1521_ GLFEI 1526_ HGATV 1531_ VPIVS 1536_ VLAPE 1541_ KLSAS 1546_ TRRRY 1551_ ETQVQ 1556_ TRLQT 1561_ SLANL 1566_ HQKSS 1571_ EIEIL 1576_ AVDLP 1581_ KETIL 1586_ QFLSL 1591_ EWDAD 1596_ EQAFN 1601_ TTVKQ 1606_ LLSRL 1611_ PKQRY 1616_ LKLVC 1621_ DEIYN 1626_ IKVEK 1631_ KVSVL 1636_ FLYSY 1641_RDDYY
1: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability (PubMed:25329545, PubMed:32610081). Plays a role as an activator of the integrated stress response (ISR) required for adaptation to amino acid starvation (By similarity). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (PubMed:32610081). Binds uncharged tRNAs (By similarity). Required for the translational induction of protein kinase PRKCH following amino acid starvation (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:26102367). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory (By similarity). Plays a role in neurite outgrowth inhibition (By similarity). Plays a proapoptotic role in response to glucose deprivation (By similarity). Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (By similarity). Plays a role in the antiviral response against alphavirus infection; impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication (By similarity)
2: (Microbial infection) Plays a role in modulating the adaptive immune response to yellow fever virus infection; promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation (PubMed:24310610)