KAT8 regulatory NSL complex subunit 3 (NSL complex protein NSL3) (Non-specific lethal 3 homolog) (Serum inhibited-related protein) (Testis development protein PRTD)
1_MAHRG 6_ GERDF 11_ QTSAR 16_ RMGTS 21_ LLFQL 26_ SVHER 31_ ELDLV 36_ FLDHS 41_ YAKPW 46_ SAHPD 51_ ASSAR 56_ PTRML 61_ FVTPR 66_ RQHES 71_ TIESD 76_ VPIDV 81_ ETVTS 86_ TPMPL 91_ YDNQK 96_ ARSVM 101_ NECER 106_ HVIFA 111_ RTDAD 116_ APPPP 121_ EDWEE 126_ HVNRT 131_ GWTMA 136_ QNKLF 141_ NKILK 146_ ALQSD 151_ RLARL 156_ ANEGA 161_ CNEPV 166_ LRRVA 171_ VDKCA 176_ RRVRQ 181_ ALASV 186_ SWDTK 191_ LIQWL 196_ HTTLV 201_ ETLSL 206_ PMLAA 211_ YLDAL 216_ QTLKG 221_ KIPTL 226_ IDRML 231_ VSSNT 236_ KTGAA 241_ GAEAL 246_ SLLLK 251_ RPWDP 256_ AVGVL 261_ SHNKP 266_ SKLPG 271_ SPLIL 276_ IASSG 281_ PSSSV 286_ FPTSR 291_ RHRFW 296_ QSQLS 301_ CLGKV 306_ IPVAT 311_ HLLNN 316_ GSGVG 321_ VLQCL 326_ EHMIG 331_ AVRSK 336_ VLEIH 341_ SHFPH 346_ KPIIL 351_ IGWNT 356_ GALVA 361_ CHVSV 366_ MEYVT 371_ AVVCL 376_ GFPLL 381_ TVDGP 386_ RGDVD 391_ DPLLD 396_ MKTPV 401_ LFVIG 406_ QNSLQ 411_ CHPEA 416_ MEDFR 421_ EKIRA 426_ ENSLV 431_ VVGGA 436_ DDNLR 441_ ISKAK 446_ KKSEG 451_ LTQSM 456_ VDRCI 461_ QDEIV 466_ DFLTG 471_ VLTRA 476_ EGHMG 481_ SEPRD 486_ QDAEK 491_ KKKPR 496_ DVARR 501_ DLAFE 506_ VPERG 511_ SRPAS 516_ PAAKL 521_ PASPS 526_ GSEDL 531_ SSVSS 536_ SPTSS 541_ PKTKV 546_ TTVTS 551_ AQKSS 556_ QIGSS 561_ QLLKR 566_ HVQRT 571_ EAVLT 576_ HKQAQ 581_ AQFAA 586_ FLKQN 591_ MLVRK 596_ ALPPG 601_ TSSCL 606_ FVPIS 611_ SEPPE 616_ EGEKE 621_ DLRVQ 626_ LKRHH 631_ PSSPL 636_ PGSKT 641_ SKRPK 646_ IKVSL 651_ ISQGD 656_ TAGGP 661_ CAPSQ 666_ GSAPE 671_ AAGGK 676_ PITMT 681_ LGQAS 686_ AGAKE 691_ LTGLL 696_ TTAKS 701_ SSSEG 706_ GVSAS 711_ PVPSV 716_ VSSST 721_ APSAL 726_ HTLQS 731_ RLVAT 736_ SPGSS 741_ LPGAT 746_ SASSL 751_ LQGLS 756_ FSLQD 761_ ISSKT 766_ SGLPA 771_ NPSPG 776_ PAPQA 781_ TSVKL 786_ PTPMQ 791_ SLGAI 796_ TTGTS 801_ TIVRT 806_ IPVAT 811_ TLSSL 816_ GATPG 821_ GKPTA 826_ IHQLL 831_ TNGGL 836_ AKLAS 841_ SLPGL 846_ AQISN 851_ QASGL 856_ KVPTT 861_ ITLTL 866_ RGQPS 871_ RITTL 876_ SPMGS 881_ GAAPS 886_ EESSS 891_ QVLPS 896_SSQRL
1: Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). Within the NSL complex, KANSL3 is required to promote KAT8 association with mitochondrial DNA (PubMed:27768893). Required for transcription of intraciliary transport genes in both ciliated and non-ciliated cells (By similarity). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells (By similarity). Also required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA (By similarity). Plays an essential role in spindle assembly during mitosis (PubMed:26243146). Acts as a microtubule minus-end binding protein which stabilizes microtubules and promotes their assembly (PubMed:26243146). Indispensable during early embryonic development where it is required for proper lineage specification and maintenance during peri-implantation development and is essential for implantation (By similarity)