E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2)
1_MASSA 6_ REHLL 11_ FVRRR 16_ NPQMR 21_ YTLSP 26_ ENLQS 31_ LAAQS 36_ SMPEN 41_ MTLQR 46_ ANSDT 51_ DLVTS 56_ ESRSS 61_ LTASM 66_ YEYTL 71_ GQAQN 76_ LIIFW 81_ DIKEE 86_ VDPSD 91_ WIGLY 96_ HIDEN 101_ SPANF 106_ WDSKN 111_ RGVTG 116_ TQKGQ 121_ IVWRI 126_ EPGPY 131_ FMEPE 136_ IKICF 141_ KYYHG 146_ ISGAL 151_ RATTP 156_ CITVK 161_ NPAVM 166_ MGAEG 171_ MEGGA 176_ SGNLH 181_ SRKLV 186_ SFTLS 191_ DLRAV 196_ GLKKG 201_ MFFNP 206_ DPYLK 211_ MSIQP 216_ GKKSS 221_ FPTCA 226_ HHGQE 231_ RRSTI 236_ ISNTT 241_ NPIWH 246_ REKYS 251_ FFALL 256_ TDVLE 261_ IEIKD 266_ KFAKS 271_ RPIIK 276_ RFLGK 281_ LTIPV 286_ QRLLE 291_ RQAIG 296_ DQMLS 301_ YNLGR 306_ RLPAD 311_ HVSGY 316_ LQFKV 321_ EVTSS 326_ VHEDA 331_ SPEAV 336_ GTILG 341_ VNSVN 346_ GDLGS 351_ PSDDE 356_ DMPGS 361_ HHDSQ 366_ VCSNG 371_ PVSED 376_ SAADG 381_ TPKHS 386_ FRTSS 391_ TLEID 396_ TEELT 401_ STSSR 406_ TSPPR 411_ GRQDS 416_ LNDYL 421_ DAIEH 426_ NGHSR 431_ PGTAT 436_ CSERS 441_ MGASP 446_ KLRSS 451_ FPTDT 456_ RLNAM 461_ LHIDS 466_ DEEDH 471_ EFQQD 476_ LGYPS 481_ SLEEE 486_ GGLIM 491_ FSRAS 496_ RADDG 501_ SLTSQ 506_ TKLED 511_ NPVEN 516_ EEAST 521_ HEAAS 526_ FEDKP 531_ ENLPE 536_ LAESS 541_ LPAGP 546_ APEEG 551_ EGGPE 556_ PQPSA 561_ DQGSA 566_ ELCGS 571_ QEVDQ 576_ PTSGA 581_ DTGTS 586_ DASGG 591_ SRRAV 596_ SETES 601_ LDQGS 606_ EPSQV 611_ SSETE 616_ PSDPA 621_ RTESV 626_ SEAST 631_ RPEGE 636_ SDLEC 641_ ADSSC 646_ NESVT 651_ TQLSS 656_ VDTRC 661_ SSLES 666_ ARFPE 671_ TPAFS 676_ SQEEE 681_ DGACA 686_ AEPTS 691_ SGPAE 696_ GSQES 701_ VCTAG 706_ SLPVV 711_ QVPSG 716_ EDEGP 721_ GAESA 726_ TVPDQ 731_ EELGE 736_ VWQRR 741_ GSLEG 746_ AAAAA 751_ ESPPQ 756_ EEGSA 761_ GEAQG 766_ TCEGA 771_ TAQEE 776_ GATGG 781_ SQANG 786_ HQPLR 791_ SLPSV 796_ RQDVS 801_ RYQRV 806_ DEALP 811_ PNWEA 816_ RIDSH 821_ GRIFY 826_ VDHVN 831_ RTTTW 836_ QRPTA 841_ PPAPQ 846_ VLQRS 851_ NSIQQ 856_ MEQLN 861_ RRYQS 866_ IRRTM 871_ TNERP 876_ EENTN 881_ AIDGA 886_ GEEAD 891_ FHQAS 896_ ADFRR 901_ ENILP 906_ HSTSR 911_ SRITL 916_ LLQSP 921_ PVKFL 926_ ISPEF 931_ FTVLH 936_ SNPSA 941_ YRMFT 946_ NNTCL 951_ KHMIT 956_ KVRRD 961_ THHFE 966_ RYQHN 971_ RDLVG 976_ FLNMF 981_ ANKQL 986_ ELPRG 991_ WEMKH 996_ DHQGK 1001_ AFFVD 1006_ HNSRT 1011_ TTFID 1016_ PRLPL 1021_ QSSRP 1026_ TSALV 1031_ HRQHL 1036_ TRQRS 1041_ HSAGE 1046_ VGEDS 1051_ RHAGP 1056_ PVLPR 1061_ PSSTF 1066_ NTVSR 1071_ PQYQD 1076_ MVPVA 1081_ YNDKI 1086_ VAFLR 1091_ QPNIF 1096_ EILQE 1101_ RQPDL 1106_ TRNHS 1111_ LREKI 1116_ QFIRT 1121_ EGTPG 1126_ LVRLS 1131_ SDADL 1136_ VMLLS 1141_ LFEEE 1146_ IMSYV 1151_ PPHAL 1156_ LHPSY 1161_ CQSPR 1166_ GSPVS 1171_ SPQNS 1176_ PGTQR 1181_ ANARA 1186_ PAPYK 1191_ RDFEA 1196_ KLRNF 1201_ YRKLE 1206_ TKGYG 1211_ QGPGK 1216_ LKLII 1221_ RRDHL 1226_ LEDAF 1231_ NQIMG 1236_ YSRKD 1241_ LQRNK 1246_ LYVTF 1251_ VGEEG 1256_ LDYSG 1261_ PSREF 1266_ FFLVS 1271_ RELFN 1276_ PYYGL 1281_ FEYSA 1286_ NDTYT 1291_ VQISP 1296_ MSAFV 1301_ DNHHE 1306_ WFRFS 1311_ GRILG 1316_ LALIH 1321_ QYLLD 1326_ AFFTR 1331_ PFYKA 1336_ LLRIL 1341_ CDLSD 1346_ LEYLD 1351_ EEFHQ 1356_ SLQWM 1361_ KDNDI 1366_ HDILD 1371_ LTFTV 1376_ NEEVF 1381_ GQITE 1386_ RELKP 1391_ GGANI 1396_ PVTEK 1401_ NKKEY 1406_ IERMV 1411_ KWRIE 1416_ RGVVQ 1421_ QTESL 1426_ VRGFY 1431_ EVVDA 1436_ RLVSV 1441_ FDARE 1446_ LELVI 1451_ AGTAE 1456_ IDLSD 1461_ WRNNT 1466_ EYRGG 1471_ YHDNH 1476_ IVIRW 1481_ FWAAV 1486_ ERFNN 1491_ EQRLR 1496_ LLQFV 1501_ TGTSS 1506_ IPYEG 1511_ FASLR 1516_ GSNGP 1521_ RRFCV 1526_ EKWGK 1531_ ITALP 1536_ RAHTC 1541_ FNRLD 1546_ LPPYP 1551_ SFSML 1556_ YEKLL 1561_ TAVEE 1566_TSTFG
1: E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (PubMed:12890487). Involved in the regulation of mitotic metaphase/anaphase transition (PubMed:24163370)