Rabankyrin-5 (Rank-5) (Ankyrin repeat and FYVE domain-containing protein 1) (Ankyrin repeats hooked to a zinc finger motif)
1_MAEEE 6_ VAKLE 11_ KHLML 16_ LRQEY 21_ VKLQK 26_ KLAET 31_ EKRCA 36_ LLAAQ 41_ ANKES 46_ SSESF 51_ ISRLL 56_ AIVAD 61_ LYEQE 66_ QYSDL 71_ KIKVG 76_ DRHIS 81_ AHKFV 86_ LAARS 91_ DSWSL 96_ ANLSS 101_ TKELD 106_ LSDAN 111_ PEVTM 116_ TMLRW 121_ IYTDE 126_ LEFRE 131_ DDVFL 136_ TELMK 141_ LANRF 146_ QLQLL 151_ RERCE 156_ KGVMS 161_ LVNVR 166_ NCIRF 171_ YQTAE 176_ ELNAS 181_ TLMNY 186_ CAEII 191_ ASHWD 196_ DLRKE 201_ DFSSM 206_ SAQLL 211_ YKMIK 216_ SKTEY 221_ PLHKA 226_ IKVER 231_ EDVVF 236_ LYLIE 241_ MDSQL 246_ PGKLN 251_ EADHN 256_ GDLAL 261_ DLALS 266_ RRLES 271_ IATTL 276_ VSHKA 281_ DVDMV 286_ DKSGW 291_ SLLHK 296_ GIQRG 301_ DLFAA 306_ TFLIK 311_ NGAFV 316_ NAATL 321_ GAQET 326_ PLHLV 331_ ALYSS 336_ KKHSA 341_ DVMSE 346_ MAQIA 351_ EALLQ 356_ AGANP 361_ NMQDS 366_ KGRTP 371_ LHVSI 376_ MAGNE 381_ YVFSQ 386_ LLQCK 391_ QLDLE 396_ LKDHE 401_ GSTAL 406_ WLAVQ 411_ HITVS 416_ SDQSV 421_ NPFED 426_ VPVVN 431_ GTSFD 436_ ENSFA 441_ ARLIQ 446_ RGSHT 451_ DAPDT 456_ ATGNC 461_ LLQRA 466_ AGAGN 471_ EAAAL 476_ FLATN 481_ GAHVN 486_ HRNKW 491_ GETPL 496_ HTACR 501_ HGLAN 506_ LTAEL 511_ LQQGA 516_ NPNLQ 521_ TEEAL 526_ PLPKE 531_ AASLT 536_ SLADS 541_ VHLQT 546_ PLHMA 551_ IAYNH 556_ PDVVS 561_ VILEQ 566_ KANAL 571_ HATNN 576_ LQIIP 581_ DFSLK 586_ DSRDQ 591_ TVLGL 596_ ALWTG 601_ MHTIA 606_ AQLLG 611_ SGAAI 616_ NDTMS 621_ DGQTL 626_ LHMAI 631_ QRQDS 636_ KSALF 641_ LLEHQ 646_ ADINV 651_ RTQDG 656_ ETALQ 661_ LAIRN 666_ QLPLV 671_ VDAIC 676_ TRGAD 681_ MSVPD 686_ EKGNP 691_ PLWLA 696_ LANNL 701_ EDIAS 706_ TLVRH 711_ GCDAT 716_ CWGPG 721_ PGGCL 726_ QTLLH 731_ RAIDE 736_ NNEPT 741_ ACFLI 746_ RSGCD 751_ VNSPR 756_ QPGAN 761_ GEGEE 766_ EARDG 771_ QTPLH 776_ LAASW 781_ GLEET 786_ VQCLL 791_ EFGAN 796_ VNAQD 801_ AEGRT 806_ PIHVA 811_ ISSQH 816_ GVIIQ 821_ LLVSH 826_ PDIHL 831_ NVRDR 836_ QGLTP 841_ FACAM 846_ TFKNN 851_ KSAEA 856_ ILKRE 861_ SGAAE 866_ QVDNK 871_ GRNFL 876_ HVAVQ 881_ NSDIE 886_ SVLFL 891_ ISVHA 896_ NVNSR 901_ VQDAS 906_ KLTPL 911_ HLAVQ 916_ AGSEI 921_ IVRNL 926_ LLAGA 931_ KVNEL 936_ TKHRQ 941_ TALHL 946_ AAQQD 951_ LPTIC 956_ SVLLE 961_ NGVDF 966_ AAVDE 971_ NGNNA 976_ LHLAV 981_ MHGRL 986_ NNIRV 991_ LLTEC 996_ TVDAE 1001_ AFNLR 1006_ GQSPL 1011_ HILGQ 1016_ YGKEN 1021_ AAAIF 1026_ DLFLE 1031_ CMPGY 1036_ PLDKP 1041_ DADGS 1046_ TVLLL 1051_ AYMKG 1056_ NANLC 1061_ RAIVR 1066_ SGARL 1071_ GVNNN 1076_ QGVNI 1081_ FNYQV 1086_ ATKQL 1091_ LFRLL 1096_ DMLSK 1101_ EPPWC 1106_ DGSYC 1111_ YECTA 1116_ RFGVT 1121_ TRKHH 1126_ CRHCG 1131_ RLLCH 1136_ KCSTK 1141_ EIPII 1146_ KFDLN 1151_ KPVRV 1156_ CNICF 1161_DVLTL
1: Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport