Gene name: WRAP73

Uniprot entry:

Q9P2S5

Protein names:

WD repeat-containing protein WRAP73 (WD repeat-containing protein 8) (WD repeat-containing protein antisense to TP73 gene)

Protein sequence:

1_MNFSE 6_ VFKLS 11_ SLLCK 16_ FSPDG 21_ KYLAS 26_ CVQYR 31_ LVVRD 36_ VNTLQ 41_ ILQLY 46_ TCLDQ 51_ IQHIE 56_ WSADS 61_ LFILC 66_ AMYKR 71_ GLVQV 76_ WSLEQ 81_ PEWHC 86_ KIDEG 91_ SAGLV 96_ ASCWS 101_ PDGRH 106_ ILNTT 111_ EFHLR 116_ ITVWS 121_ LCTKS 126_ VSYIK 131_ YPKAC 136_ LQGIT 141_ FTRDG 146_ RYMAL 151_ AERRD 156_ CKDYV 161_ SIFVC 166_ SDWQL 171_ LRHFD 176_ TDTQD 181_ LTGIE 186_ WAPNG 191_ CVLAV 196_ WDTCL 201_ EYKIL 206_ LYSLD 211_ GRLLS 216_ TYSAY 221_ EWSLG 226_ IKSVA 231_ WSPSS 236_ QFLAV 241_ GSYDG 246_ KVRIL 251_ NHVTW 256_ KMITE 261_ FGHPA 266_ AINDP 271_ KIVVY 276_ KEAEK 281_ SPQLG 286_ LGCLS 291_ FPPPR 296_ AGAGP 301_ LPSSE 306_ SKYEI 311_ ASVPV 316_ SLQTL 321_ KPVTD 326_ RANPK 331_ IGIGM 336_ LAFSP 341_ DSYFL 346_ ATRND 351_ NIPNA 356_ VWVWD 361_ IQKLR 366_ LFAVL 371_ EQLSP 376_ VRAFQ 381_ WDPQQ 386_ PRLAI 391_ CTGGS 396_ RLYLW 401_ SPAGC 406_ MSVQV 411_ PGEGD 416_ FAVLS 421_ LCWHL 426_ SGDSM 431_ ALLSK 436_ DHFCL 441_ CFLET 446_ EAVVG 451_TACRQ

Protein annotations

Protein functions:

1: The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology (PubMed:26545777). Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal body during ciliogenesis; may promote docking of RAB8A- and ARL13B-containing vesicles (PubMed:26675238)