GMP reductase 2 (GMPR 2) (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 2) (Guanosine monophosphate reductase 2)
1_MPHID 6_ NDVKL 11_ DFKDV 16_ LLRPK 21_ RSTLK 26_ SRSEV 31_ DLTRS 36_ FSFRN 41_ SKQTY 46_ SGVPI 51_ IAANM 56_ DTVGT 61_ FEMAK 66_ VLCKF 71_ SLFTA 76_ VHKHY 81_ SLVQW 86_ QEFAG 91_ QNPDC 96_ LEHLA 101_ ASSGT 106_ GSSDF 111_ EQLEQ 116_ ILEAI 121_ PQVKY 126_ ICLDV 131_ ANGYS 136_ EHFVE 141_ FVKDV 146_ RKRFP 151_ QHTIM 156_ AGNVV 161_ TGEMV 166_ EELIL 171_ SGADI 176_ IKVGI 181_ GPGSV 186_ CTTRK 191_ KTGVG 196_ YPQLS 201_ AVMEC 206_ ADAAH 211_ GLKGH 216_ IISDG 221_ GCSCP 226_ GDVAK 231_ AFGAG 236_ ADFVM 241_ LGGML 246_ AGHSE 251_ SGGEL 256_ IERDG 261_ KKYKL 266_ FYGMS 271_ SEMAM 276_ KKYAG 281_ GVAEY 286_ RASEG 291_ KTVEV 296_ PFKGD 301_ VEHTI 306_ RDILG 311_ GIRST 316_ CTYVG 321_ AAKLK 326_ ELSRR 331_ TTFIR 336_ VTQQV 341_NPIFS
1: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (PubMed:12009299, PubMed:12669231, PubMed:16359702, PubMed:22037469). Plays a role in modulating cellular differentiation (PubMed:12669231)