Vesicular glutamate transporter 1 (VGluT1) (Brain-specific Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 7)
1_MEFRQ 6_ EEFRK 11_ LAGRA 16_ LGKLH 21_ RLLEK 26_ RQEGA 31_ ETLEL 36_ SADGR 41_ PVTTQ 46_ TRDPP 51_ VVDCT 56_ CFGLP 61_ RRYII 66_ AIMSG 71_ LGFCI 76_ SFGIR 81_ CNLGV 86_ AIVSM 91_ VNNST 96_ THRGG 101_ HVVVQ 106_ KAQFS 111_ WDPET 116_ VGLIH 121_ GSFFW 126_ GYIVT 131_ QIPGG 136_ FICQK 141_ FAANR 146_ VFGFA 151_ IVATS 156_ TLNML 161_ IPSAA 166_ RVHYG 171_ CVIFV 176_ RILQG 181_ LVEGV 186_ TYPAC 191_ HGIWS 196_ KWAPP 201_ LERSR 206_ LATTA 211_ FCGSY 216_ AGAVV 221_ AMPLA 226_ GVLVQ 231_ YSGWS 236_ SVFYV 241_ YGSFG 246_ IFWYL 251_ FWLLV 256_ SYESP 261_ ALHPS 266_ ISEEE 271_ RKYIE 276_ DAIGE 281_ SAKLM 286_ NPLTK 291_ FSTPW 296_ RRFFT 301_ SMPVY 306_ AIIVA 311_ NFCRS 316_ WTFYL 321_ LLISQ 326_ PAYFE 331_ EVFGF 336_ EISKV 341_ GLVSA 346_ LPHLV 351_ MTIIV 356_ PIGGQ 361_ IADFL 366_ RSRRI 371_ MSTTN 376_ VRKLM 381_ NCGGF 386_ GMEAT 391_ LLLVV 396_ GYSHS 401_ KGVAI 406_ SFLVL 411_ AVGFS 416_ GFAIS 421_ GFNVN 426_ HLDIA 431_ PRYAS 436_ ILMGI 441_ SNGVG 446_ TLSGM 451_ VCPII 456_ VGAMT 461_ KHKTR 466_ EEWQY 471_ VFLIA 476_ SLVHY 481_ GGVIF 486_ YGVFA 491_ SGEKQ 496_ PWAEP 501_ EEMSE 506_ EKCGF 511_ VGHDQ 516_ LAGSD 521_ DSEME 526_ DEAEP 531_ PGAPP 536_ APPPS 541_ YGATH 546_ STFQP 551_PRPPP
1: Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed:10820226). At the synaptic vesicle membrane, mainly functions as an uniporter which transports preferentially L-glutamate but also phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (By similarity). The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane (By similarity). In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification (By similarity). Moreover, may function as a K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular glutamate uptake (By similarity). The vesicular K(+)/H(+) antiport activity is electroneutral (By similarity). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (PubMed:10820226). The symporter activity is driven by an inside negative membrane potential and is electrogenic (By similarity). Is necessary for synaptic signaling of visual-evoked responses from photoreceptors (By similarity)