Vesicular glutamate transporter 2 (VGluT2) (Differentiation-associated BNPI) (Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 6)
1_MESVK 6_ QRILA 11_ PGKEG 16_ LKNFA 21_ GKSLG 26_ QIYRV 31_ LEKKQ 36_ DTGET 41_ IELTE 46_ DGKPL 51_ EVPER 56_ KAPLC 61_ DCTCF 66_ GLPRR 71_ YIIAI 76_ MSGLG 81_ FCISF 86_ GIRCN 91_ LGVAI 96_ VDMVN 101_ NSTIH 106_ RGGKV 111_ IKEKA 116_ KFNWD 121_ PETVG 126_ MIHGS 131_ FFWGY 136_ IITQI 141_ PGGYI 146_ ASRLA 151_ ANRVF 156_ GAAIL 161_ LTSTL 166_ NMLIP 171_ SAARV 176_ HYGCV 181_ IFVRI 186_ LQGLV 191_ EGVTY 196_ PACHG 201_ IWSKW 206_ APPLE 211_ RSRLA 216_ TTSFC 221_ GSYAG 226_ AVIAM 231_ PLAGI 236_ LVQYT 241_ GWSSV 246_ FYVYG 251_ SFGMV 256_ WYMFW 261_ LLVSY 266_ ESPAK 271_ HPTIT 276_ DEERR 281_ YIEES 286_ IGESA 291_ NLLGA 296_ MEKFK 301_ TPWRK 306_ FFTSM 311_ PVYAI 316_ IVANF 321_ CRSWT 326_ FYLLL 331_ ISQPA 336_ YFEEV 341_ FGFEI 346_ SKVGM 351_ LSAVP 356_ HLVMT 361_ IIVPI 366_ GGQIA 371_ DFLRS 376_ KQILS 381_ TTTVR 386_ KIMNC 391_ GGFGM 396_ EATLL 401_ LVVGY 406_ SHTRG 411_ VAISF 416_ LVLAV 421_ GFSGF 426_ AISGF 431_ NVNHL 436_ DIAPR 441_ YASIL 446_ MGISN 451_ GVGTL 456_ SGMVC 461_ PIIVG 466_ AMTKN 471_ KSREE 476_ WQYVF 481_ LIAAL 486_ VHYGG 491_ VIFYA 496_ IFASG 501_ EKQPW 506_ ADPEE 511_ TSEEK 516_ CGFIH 521_ EDELD 526_ EETGD 531_ ITQNY 536_ INYGT 541_ TKSYG 546_ ATTQA 551_ NGGWP 556_ SGWEK 561_ KEEFV 566_ QGEVQ 571_ DSHSY 576_KDRVD
1: Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed:11698620, PubMed:33440152). At the synaptic vesicle membrane, mainly functions as a uniporter which transports preferentially L-glutamate but also, phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (PubMed:11698620). The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane (PubMed:11698620). In addition, functions as a chloride channel that allows the chloride permeation through the synaptic vesicle membrane therefore affects the proton electrochemical gradient and promotes synaptic vesicles acidification (By similarity). Moreover, functions as a vesicular K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular glutamate uptake (By similarity). The vesicular H(+)/H(+) antiport activity is electroneutral (By similarity). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (Probable) (PubMed:10820226). The symporter activity is driven by an inside negative membrane potential and is electrogenic (Probable). Also involved in the regulation of retinal hyaloid vessel regression during postnatal development (By similarity). May also play a role in the endocrine glutamatergic system of other tissues such as pineal gland and pancreas (By similarity)