Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 (EC 2.4.1.135) (Beta-1,3-glucuronyltransferase 1) (Glucuronosyltransferase P) (GlcAT-P) (UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase) (GlcUAT-P)
1_MPKRR 6_ DILAI 11_ VLIVL 16_ PWTLL 21_ ITVWH 26_ QSTLA 31_ PLLAV 36_ HKDEG 41_ SDPRR 46_ ETPPG 51_ ADPRE 56_ YCTSD 61_ RDIVE 66_ VVRTE 71_ YVYTR 76_ PPPWS 81_ DTLPT 86_ IHVVT 91_ PTYSR 96_ PVQKA 101_ ELTRM 106_ ANTLL 111_ HVPNL 116_ HWLVV 121_ EDAPR 126_ RTPLT 131_ ARLLR 136_ DTGLN 141_ YTHLH 146_ VETPR 151_ NYKLR 156_ GDARD 161_ PRIPR 166_ GTMQR 171_ NLALR 176_ WLRET 181_ FPRNS 186_ SQPGV 191_ VYFAD 196_ DDNTY 201_ SLELF 206_ EEMRS 211_ TRRVS 216_ VWPVA 221_ FVGGL 226_ RYEAP 231_ RVNGA 236_ GKVVG 241_ WKTVF 246_ DPHRP 251_ FAIDM 256_ AGFAV 261_ NLRLI 266_ LQRSQ 271_ AYFKL 276_ RGVKG 281_ GYQES 286_ SLLRE 291_ LVTLN 296_ DLEPK 301_ AANCT 306_ KILVW 311_ HTRTE 316_ KPVLV 321_ NEGKK 326_GFTDP
1: Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group