UV radiation resistance-associated gene protein (p63)
1_MSASA 6_ SVGGP 11_ VPQPP 16_ PGPAA 21_ ALPPG 26_ SAARA 31_ LHVEL 36_ PSQQR 41_ RLRHL 46_ RNIAA 51_ RNIVN 56_ RNGHQ 61_ LLDTY 66_ FTLHL 71_ CSTEK 76_ IYKEF 81_ YRSEV 86_ IKNSL 91_ NPTWR 96_ SLDFG 101_ IMPDR 106_ LDTSV 111_ SCFVV 116_ KIWGG 121_ KENIY 126_ QLLIE 131_ WKVCL 136_ DGLKY 141_ LGQQI 146_ HARNQ 151_ NEIIF 156_ GLNDG 161_ YYGAP 166_ FEHKG 171_ YSNAQ 176_ KTILL 181_ QVDQN 186_ CVRNS 191_ YDVFS 196_ LLRLH 201_ RAQCA 206_ IKQTQ 211_ VTVQK 216_ IGKEI 221_ EEKLR 226_ LTSTS 231_ NELKK 236_ KSECL 241_ QLKIL 246_ VLQNE 251_ LERQK 256_ KALGR 261_ EVALL 266_ HKQQI 271_ ALQDK 276_ GSAFS 281_ AEHLK 286_ LQLQK 291_ ESLNE 296_ LRKEC 301_ TAKRE 306_ LFLKT 311_ NAQLT 316_ IRCRQ 321_ LLSEL 326_ SYIYP 331_ IDLNE 336_ HKDYF 341_ VCGVK 346_ LPNSE 351_ DFQAK 356_ DDGSI 361_ AVALG 366_ YTAHL 371_ VSMIS 376_ FFLQV 381_ PLRYP 386_ IIHKG 391_ SRSTI 396_ KDNIN 401_ DKLTE 406_ KEREF 411_ PLYPK 416_ GGEKL 421_ QFDYG 426_ VYLLN 431_ KNIAQ 436_ LRYQH 441_ GLGTP 446_ DLRQT 451_ LPNLK 456_ NFMEH 461_ GLMVR 466_ CDRHH 471_ TSSAI 476_ PVPKR 481_ QSSIF 486_ GGADV 491_ GFSGG 496_ IPSPD 501_ KGHRK 506_ RASSE 511_ NERLQ 516_ YKTPP 521_ PSYNS 526_ ALAQP 531_ VTTVP 536_ SMGET 541_ ERKIT 546_ SLSSS 551_ LDTSL 556_ DFSKE 561_ NKKKG 566_ EDLVG 571_ SLNGG 576_ HANVH 581_ PSQEQ 586_ GEALS 591_ GHRAT 596_ VNGTL 601_ LPSEQ 606_ AGSAS 611_ VQLPG 616_ EFHPV 621_ SEAEL 626_ CCTVE 631_ QAEEI 636_ IGLEA 641_ TGFAS 646_ GDQLE 651_ AFNCI 656_ PVDSA 661_ VAVEC 666_ DEQVL 671_ GEFEE 676_ FSRRI 681_ YALNE 686_ NVSSF 691_RRPRR
1: Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:16799551, PubMed:18552835, PubMed:20643123, PubMed:24056303, PubMed:28306502). During autophagy acts as a regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3 (PubMed:16799551, PubMed:20643123, PubMed:24056303, PubMed:28306502). Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 (PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events (PubMed:18552835, PubMed:28306502). Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion (PubMed:24550300). In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly (PubMed:24550300)
2: Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required for centrosome stability and proper chromosome segregation (PubMed:22542840)