Methyl-CpG-binding domain protein 2 (Demethylase) (DMTase) (Methyl-CpG-binding protein MBD2)
1_MRAHP 6_ GGGRC 11_ CPEQE 16_ EGESA 21_ AGGSG 26_ AGGDS 31_ AIEQG 36_ GQGSA 41_ LAPSP 46_ VSGVR 51_ REGAR 56_ GGGRG 61_ RGRWK 66_ QAGRG 71_ GGVCG 76_ RGRGR 81_ GRGRG 86_ RGRGR 91_ GRGRG 96_ RPPSG 101_ GSGLG 106_ GDGGG 111_ CGGGG 116_ SGGGG 121_ APRRE 126_ PVPFP 131_ SGSAG 136_ PGPRG 141_ PRATE 146_ SGKRM 151_ DCPAL 156_ PPGWK 161_ KEEVI 166_ RKSGL 171_ SAGKS 176_ DVYYF 181_ SPSGK 186_ KFRSK 191_ PQLAR 196_ YLGNT 201_ VDLSS 206_ FDFRT 211_ GKMMP 216_ SKLQK 221_ NKQRL 226_ RNDPL 231_ NQNKG 236_ KPDLN 241_ TTLPI 246_ RQTAS 251_ IFKQP 256_ VTKVT 261_ NHPSN 266_ KVKSD 271_ PQRMN 276_ EQPRQ 281_ LFWEK 286_ RLQGL 291_ SASDV 296_ TEQII 301_ KTMEL 306_ PKGLQ 311_ GVGPG 316_ SNDET 321_ LLSAV 326_ ASALH 331_ TSSAP 336_ ITGQV 341_ SAAVE 346_ KNPAV 351_ WLNTS 356_ QPLCK 361_ AFIVT 366_ DEDIR 371_ KQEER 376_ VQQVR 381_ KKLEE 386_ ALMAD 391_ ILSRA 396_ ADTEE 401_ MDIEM 406_DSGDE
1: Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides (PubMed:9774669). Binds hemimethylated DNA as well (PubMed:10947852, PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases to chromatin (PubMed:10471499, PubMed:10947852). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Acts as a transcriptional repressor and plays a role in gene silencing (PubMed:10471499, PubMed:10947852, PubMed:16415179). Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression (PubMed:16415179). May enhance the activation of some unmethylated cAMP-responsive promoters (PubMed:12665568)