DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) (EC 2.1.1.37) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB)
1_MKGDT 6_ RHLNG 11_ EEDAG 16_ GREDS 21_ ILVNG 26_ ACSDQ 31_ SSDSP 36_ PILEA 41_ IRTPE 46_ IRGRR 51_ SSSRL 56_ SKREV 61_ SSLLS 66_ YTQDL 71_ TGDGD 76_ GEDGD 81_ GSDTP 86_ VMPKL 91_ FRETR 96_ TRSES 101_ PAVRT 106_ RNNNS 111_ VSSRE 116_ RHRPS 121_ PRSTR 126_ GRQGR 131_ NHVDE 136_ SPVEF 141_ PATRS 146_ LRRRA 151_ TASAG 156_ TPWPS 161_ PPSSY 166_ LTIDL 171_ TDDTE 176_ DTHGT 181_ PQSSS 186_ TPYAR 191_ LAQDS 196_ QQGGM 201_ ESPQV 206_ EADSG 211_ DGDSS 216_ EYQDG 221_ KEFGI 226_ GDLVW 231_ GKIKG 236_ FSWWP 241_ AMVVS 246_ WKATS 251_ KRQAM 256_ SGMRW 261_ VQWFG 266_ DGKFS 271_ EVSAD 276_ KLVAL 281_ GLFSQ 286_ HFNLA 291_ TFNKL 296_ VSYRK 301_ AMYHA 306_ LEKAR 311_ VRAGK 316_ TFPSS 321_ PGDSL 326_ EDQLK 331_ PMLEW 336_ AHGGF 341_ KPTGI 346_ EGLKP 351_ NNTQP 356_ VVNKS 361_ KVRRA 366_ GSRKL 371_ ESRKY 376_ ENKTR 381_ RRTAD 386_ DSATS 391_ DYCPA 396_ PKRLK 401_ TNCYN 406_ NGKDR 411_ GDEDQ 416_ SREQM 421_ ASDVA 426_ NNKSS 431_ LEDGC 436_ LSCGR 441_ KNPVS 446_ FHPLF 451_ EGGLC 456_ QTCRD 461_ RFLEL 466_ FYMYD 471_ DDGYQ 476_ SYCTV 481_ CCEGR 486_ ELLLC 491_ SNTSC 496_ CRCFC 501_ VECLE 506_ VLVGT 511_ GTAAE 516_ AKLQE 521_ PWSCY 526_ MCLPQ 531_ RCHGV 536_ LRRRK 541_ DWNVR 546_ LQAFF 551_ TSDTG 556_ LEYEA 561_ PKLYP 566_ AIPAA 571_ RRRPI 576_ RVLSL 581_ FDGIA 586_ TGYLV 591_ LKELG 596_ IKVGK 601_ YVASE 606_ VCEES 611_ IAVGT 616_ VKHEG 621_ NIKYV 626_ NDVRN 631_ ITKKN 636_ IEEWG 641_ PFDLV 646_ IGGSP 651_ CNDLS 656_ NVNPA 661_ RKGLY 666_ EGTGR 671_ LFFEF 676_ YHLLN 681_ YSRPK 686_ EGDDR 691_ PFFWM 696_ FENVV 701_ AMKVG 706_ DKRDI 711_ SRFLE 716_ CNPVM 721_ IDAIK 726_ VSAAH 731_ RARYF 736_ WGNLP 741_ GMNRP 746_ VIASK 751_ NDKLE 756_ LQDCL 761_ EYNRI 766_ AKLKK 771_ VQTIT 776_ TKSNS 781_ IKQGK 786_ NQLFP 791_ VVMNG 796_ KEDVL 801_ WCTEL 806_ ERIFG 811_ FPVHY 816_ TDVSN 821_ MGRGA 826_ RQKLL 831_ GRSWS 836_ VPVIR 841_ HLFAP 846_LKDYF
1: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Functions as a transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells (PubMed:27153398)