Melanoma-associated antigen C2 (Cancer/testis antigen 10) (CT10) (Hepatocellular carcinoma-associated antigen 587) (MAGE-C2 antigen) (MAGE-E1 antigen)
1_MPPVP 6_ GVPFR 11_ NVDND 16_ SPTSV 21_ ELEDW 26_ VDAQH 31_ PTDEE 36_ EEEAS 41_ SASST 46_ LYLVF 51_ SPSSF 56_ STSSS 61_ LILGG 66_ PEEEE 71_ VPSGV 76_ IPNLT 81_ ESIPS 86_ SPPQG 91_ PPQGP 96_ SQSPL 101_ SSCCS 106_ SFSWS 111_ SFSEE 116_ SSSQK 121_ GEDTG 126_ TCQGL 131_ PDSES 136_ SFTYT 141_ LDEKV 146_ AELVE 151_ FLLLK 156_ YEAEE 161_ PVTEA 166_ EMLMI 171_ VIKYK 176_ DYFPV 181_ ILKRA 186_ REFME 191_ LLFGL 196_ ALIEV 201_ GPDHF 206_ CVFAN 211_ TVGLT 216_ DEGSD 221_ DEGMP 226_ ENSLL 231_ IIILS 236_ VIFIK 241_ GNCAS 246_ EEVIW 251_ EVLNA 256_ VGVYA 261_ GREHF 266_ VYGEP 271_ RELLT 276_ KVWVQ 281_ GHYLE 286_ YREVP 291_ HSSPP 296_ YYEFL 301_ WGPRA 306_ HSESI 311_ KKKVL 316_ EFLAK 321_ LNNTV 326_ PSSFP 331_ SWYKD 336_ ALKDV 341_ EERVQ 346_ ATIDT 351_ ADDAT 356_ VMASE 361_ SLSVM 366_SSNVS
1: Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex