Coatomer subunit gamma-2 (Gamma-2-coat protein) (Gamma-2-COP)
1_MIKKF 6_ DKKDE 11_ ESGSG 16_ SNPFQ 21_ HLEKS 26_ AVLQE 31_ ARIFN 36_ ETPIN 41_ PRRCL 46_ HILTK 51_ ILYLL 56_ NQGEH 61_ FGTTE 66_ ATEAF 71_ FAMTR 76_ LFQSN 81_ DQTLR 86_ RMCYL 91_ TIKEM 96_ ATISE 101_ DVIIV 106_ TSSLT 111_ KDMTG 116_ KEDVY 121_ RGPAI 126_ RALCR 131_ ITDGT 136_ MLQAI 141_ ERYMK 146_ QAIVD 151_ KVSSV 156_ SSSAL 161_ VSSLH 166_ MMKIS 171_ YDVVK 176_ RWINE 181_ AQEAA 186_ SSDNI 191_ MVQYH 196_ ALGVL 201_ YHLRK 206_ NDRLA 211_ VSKML 216_ NKFTK 221_ SGLKS 226_ QFAYC 231_ MLIRI 236_ ASRLL 241_ KETED 246_ GHESP 251_ LFDFI 256_ ESCLR 261_ NKHEM 266_ VIYEA 271_ ASAII 276_ HLPNC 281_ TAREL 286_ APAVS 291_ VLQLF 296_ CSSPK 301_ PALRY 306_ AAVRT 311_ LNKVA 316_ MKHPS 321_ AVTAC 326_ NLDLE 331_ NLITD 336_ SNRSI 341_ ATLAI 346_ TTLLK 351_ TGSES 356_ SVDRL 361_ MKQIS 366_ SFVSE 371_ ISDEF 376_ KVVVV 381_ QAISA 386_ LCQKY 391_ PRKHS 396_ VMMTF 401_ LSNML 406_ RDDGG 411_ FEYKR 416_ AIVDC 421_ IISIV 426_ EENPE 431_ SKEAG 436_ LAHLC 441_ EFIED 446_ CEHTV 451_ LATKI 456_ LHLLG 461_ KEGPR 466_ TPVPS 471_ KYIRF 476_ IFNRV 481_ VLENE 486_ AVRAA 491_ AVSAL 496_ AKFGA 501_ QNESL 506_ LPSIL 511_ VLLQR 516_ CMMDT 521_ DDEVR 526_ DRATF 531_ YLNVL 536_ QQRQM 541_ ALNAT 546_ YIFNG 551_ LTVSV 556_ PGMEK 561_ ALHQY 566_ TLEPS 571_ EKPFD 576_ MKSIP 581_ LAMAP 586_ VFEQK 591_ AEITL 596_ VATKP 601_ EKLAP 606_ SRQDI 611_ FQEQL 616_ AAIPE 621_ FLNIG 626_ PLFKS 631_ SEPVQ 636_ LTEAE 641_ TEYFV 646_ RCIKH 651_ MFTNH 656_ IVFQF 661_ DCTNT 666_ LNDQL 671_ LEKVT 676_ VQMEP 681_ SDSYE 686_ VLSCI 691_ PAPSL 696_ PYNQP 701_ GICYT 706_ LVRLP 711_ DDDPT 716_ AVAGS 721_ FSCTM 726_ KFTVR 731_ DCDPN 736_ TGVPD 741_ EDGYD 746_ DEYVL 751_ EDLEV 756_ TVSDH 761_ IQKVL 766_ KPNFA 771_ AAWEE 776_ VGDTF 781_ EKEET 786_ FALSS 791_ TKTLE 796_ EAVNN 801_ IITFL 806_ GMQPC 811_ ERSDK 816_ VPENK 821_ NSHSL 826_ YLAGI 831_ FRGGY 836_ DLLVR 841_ SRLAL 846_ ADGVT 851_ MQVTV 856_ RSKER 861_ TPVDV 866_ILASV
1: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity)