Interleukin-36 receptor antagonist protein (IL-36Ra) (FIL1 delta) (IL-1-related protein 3) (IL-1RP3) (Interleukin-1 HY1) (IL-1HY1) (Interleukin-1 delta) (IL-1 delta) (Interleukin-1 family member 5) (IL-1F5) (Interleukin-1 receptor antagonist homolog 1) (IL-1ra homolog 1) (Interleukin-1-like protein 1) (IL-1L1)
1_MVLSG 6_ ALCFR 11_ MKDSA 16_ LKVLY 21_ LHNNQ 26_ LLAGG 31_ LHAGK 36_ VIKGE 41_ EISVV 46_ PNRWL 51_ DASLS 56_ PVILG 61_ VQGGS 66_ QCLSC 71_ GVGQE 76_ PTLTL 81_ EPVNI 86_ MELYL 91_ GAKES 96_ KSFTF 101_ YRRDM 106_ GLTSS 111_ FESAA 116_ YPGWF 121_ LCTVP 126_ EADQP 131_ VRLTQ 136_ LPENG 141_ GWNAP 146_ITDFY
1: Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR