COMM domain-containing protein 3 (Protein Bup) (Protein PIL)
1_MELSE 6_ SVQKG 11_ FQMLA 16_ DPRSF 21_ DSNAF 26_ TLLLR 31_ AAFQS 36_ LLDAQ 41_ ADEAV 46_ LDHPD 51_ LKHID 56_ PVVLK 61_ HCHAA 66_ AATYI 71_ LEAGK 76_ HRADK 81_ STLST 86_ YLEDC 91_ KFDRE 96_ RIELF 101_ CTEYQ 106_ NNKNS 111_ LEILL 116_ GSIGR 121_ SLPHI 126_ TDVSW 131_ RLEYQ 136_ IKTNQ 141_ LHRMY 146_ RPAYL 151_ VTLSV 156_ QNTDS 161_ PSYPE 166_ ISFSC 171_ SMEQL 176_ QDLVG 181_ KLKDA 186_SKSLE
1: Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203)