ATP-binding cassette sub-family D member 2 (EC 3.1.2.-) (EC 7.6.2.-) (Adrenoleukodystrophy-like 1) (Adrenoleukodystrophy-related protein) (hALDR)
1_MTHML 6_ NAAAD 11_ RVKWT 16_ RSSAA 21_ KRAAC 26_ LVAAA 31_ YALKT 36_ LYPII 41_ GKRLK 46_ QSGHG 51_ KKKAA 56_ AYPAA 61_ ENTEI 66_ LHCTE 71_ TICEK 76_ PSPGV 81_ NADFF 86_ KQLLE 91_ LRKIL 96_ FPKLV 101_ TTETG 106_ WLCLH 111_ SVALI 116_ SRTFL 121_ SIYVA 126_ GLDGK 131_ IVKSI 136_ VEKKP 141_ RTFII 146_ KLIKW 151_ LMIAI 156_ PATFV 161_ NSAIR 166_ YLECK 171_ LALAF 176_ RTRLV 181_ DHAYE 186_ TYFTN 191_ QTYYK 196_ VINMD 201_ GRLAN 206_ PDQSL 211_ TEDIM 216_ MFSQS 221_ VAHLY 226_ SNLTK 231_ PILDV 236_ MLTSY 241_ TLIQT 246_ ATSRG 251_ ASPIG 256_ PTLLA 261_ GLVVY 266_ ATAKV 271_ LKACS 276_ PKFGK 281_ LVAEE 286_ AHRKG 291_ YLRYV 296_ HSRII 301_ ANVEE 306_ IAFYR 311_ GHKVE 316_ MKQLQ 321_ KSYKA 326_ LADQM 331_ NLILS 336_ KRLWY 341_ IMIEQ 346_ FLMKY 351_ VWSSS 356_ GLIMV 361_ AIPII 366_ TATGF 371_ ADGED 376_ GQKQV 381_ MVSER 386_ TEAFT 391_ TARNL 396_ LASGA 401_ DAIER 406_ IMSSY 411_ KEVTE 416_ LAGYT 421_ ARVYN 426_ MFWVF 431_ DEVKR 436_ GIYKR 441_ TAVIQ 446_ ESESH 451_ SKNGA 456_ KVELP 461_ LSDTL 466_ AIKGK 471_ VIDVD 476_ HGIIC 481_ ENVPI 486_ ITPAG 491_ EVVAS 496_ RLNFK 501_ VEEGM 506_ HLLIT 511_ GPNGC 516_ GKSSL 521_ FRILS 526_ GLWPV 531_ YEGVL 536_ YKPPP 541_ QHMFY 546_ IPQRP 551_ YMSLG 556_ SLRDQ 561_ VIYPD 566_ SVDDM 571_ HDKGY 576_ TDQDL 581_ ERILH 586_ NVHLY 591_ HIVQR 596_ EGGWD 601_ AVMDW 606_ KDVLS 611_ GGEKQ 616_ RMGMA 621_ RMFYH 626_ KPKYA 631_ LLDEC 636_ TSAVS 641_ IDVEG 646_ KIFQA 651_ AKGAG 656_ ISLLS 661_ ITHRP 666_ SLWKY 671_ HTHLL 676_ QFDGE 681_ GGWRF 686_ EQLDT 691_ AIRLT 696_ LSEEK 701_ QKLES 706_ QLAGI 711_ PKMQQ 716_ RLNEL 721_ CKILG 726_ EDSVL 731_KTIKN
1: ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen (PubMed:21145416, PubMed:29397936). Like ABCD1 seems to have fatty acyl-CoA thioesterase (ACOT) and ATPase activities, according to this model, VLCFA-CoA as free VLCFA is transpoted in an ATP-dependent manner into peroxisomes after the hydrolysis of VLCFA-CoA mediated by the ACOT activity of ABCD2 (Probable) (PubMed:29397936). Shows overlapping substrate specificities with ABCD1 toward saturated fatty acids (FA) and monounsaturated FA (MUFA) but has a distinct substrate preference for shorter VLCFA (C22:0) and polyunsaturated fatty acid (PUFA) such as C22:6-CoA and C24:6-CoA (in vitro) (PubMed:21145416). Thus, may play a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation (PubMed:21145416)