Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1-alpha) (PPAR-gamma coactivator 1-alpha) (PPARGC-1-alpha) (Ligand effect modulator 6)
1_MAWDM 6_ CNQDS 11_ ESVWS 16_ DIECA 21_ ALVGE 26_ DQPLC 31_ PDLPE 36_ LDLSE 41_ LDVND 46_ LDTDS 51_ FLGGL 56_ KWCSD 61_ QSEII 66_ SNQYN 71_ NEPSN 76_ IFEKI 81_ DEENE 86_ ANLLA 91_ VLTET 96_ LDSLP 101_ VDEDG 106_ LPSFD 111_ ALTDG 116_ DVTTD 121_ NEASP 126_ SSMPD 131_ GTPPP 136_ QEAEE 141_ PSLLK 146_ KLLLA 151_ PANTQ 156_ LSYNE 161_ CSGLS 166_ TQNHA 171_ NHNHR 176_ IRTNP 181_ AIVKT 186_ ENSWS 191_ NKAKS 196_ ICQQQ 201_ KPQRR 206_ PCSEL 211_ LKYLT 216_ TNDDP 221_ PHTKP 226_ TENRN 231_ SSRDK 236_ CTSKK 241_ KSHTQ 246_ SQSQH 251_ LQAKP 256_ TTLSL 261_ PLTPE 266_ SPNDP 271_ KGSPF 276_ ENKTI 281_ ERTLS 286_ VELSG 291_ TAGLT 296_ PPTTP 301_ PHKAN 306_ QDNPF 311_ RASPK 316_ LKSSC 321_ KTVVP 326_ PPSKK 331_ PRYSE 336_ SSGTQ 341_ GNNST 346_ KKGPE 351_ QSELY 356_ AQLSK 361_ SSVLT 366_ GGHEE 371_ RKTKR 376_ PSLRL 381_ FGDHD 386_ YCQSI 391_ NSKTE 396_ ILINI 401_ SQELQ 406_ DSRQL 411_ ENKDV 416_ SSDWQ 421_ GQICS 426_ STDSD 431_ QCYLR 436_ ETLEA 441_ SKQVS 446_ PCSTR 451_ KQLQD 456_ QEIRA 461_ ELNKH 466_ FGHPS 471_ QAVFD 476_ DEADK 481_ TGELR 486_ DSDFS 491_ NEQFS 496_ KLPMF 501_ INSGL 506_ AMDGL 511_ FDDSE 516_ DESDK 521_ LSYPW 526_ DGTQS 531_ YSLFN 536_ VSPSC 541_ SSFNS 546_ PCRDS 551_ VSPPK 556_ SLFSQ 561_ RPQRM 566_ RSRSR 571_ SFSRH 576_ RSCSR 581_ SPYSR 586_ SRSRS 591_ PGSRS 596_ SSRSC 601_ YYYES 606_ SHYRH 611_ RTHRN 616_ SPLYV 621_ RSRSR 626_ SPYSR 631_ RPRYD 636_ SYEEY 641_ QHERL 646_ KREEY 651_ RREYE 656_ KRESE 661_ RAKQR 666_ ERQRQ 671_ KAIEE 676_ RRVIY 681_ VGKIR 686_ PDTTR 691_ TELRD 696_ RFEVF 701_ GEIEE 706_ CTVNL 711_ RDDGD 716_ SYGFI 721_ TYRYT 726_ CDAFA 731_ ALENG 736_ YTLRR 741_ SNETD 746_ FELYF 751_ CGRKQ 756_ FFKSN 761_ YADLD 766_ SNSDD 771_ FDPAS 776_ TKSKY 781_ DSLDF 786_ DSLLK 791_EAQRS
1: Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:10713165, PubMed:20005308, PubMed:21376232, PubMed:28363985, PubMed:32433991). Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter (PubMed:10713165, PubMed:20005308, PubMed:21376232). Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis (PubMed:10713165, PubMed:20005308, PubMed:21376232). Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism (PubMed:10713165, PubMed:20005308, PubMed:21376232). Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program (PubMed:16753578, PubMed:23142079). Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner (PubMed:23836911). Also involved in the integration of the circadian rhythms and energy metabolism (By similarity). Required for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity)