Protein UXT (Androgen receptor trapped clone 27 protein) (ART-27) (Ubiquitously expressed transcript protein)
1_MATPP 6_ KRRAV 11_ EATGE 16_ KVLRY 21_ ETFIS 26_ DVLQR 31_ DLRKV 36_ LDHRD 41_ KVYEQ 46_ LAKYL 51_ QLRNV 56_ IERLQ 61_ EAKHS 66_ ELYMQ 71_ VDLGC 76_ NFFVD 81_ TVVPD 86_ TSRIY 91_ VALGY 96_ GFFLE 101_ LTLAE 106_ ALKFI 111_ DRKSS 116_ LLTEL 121_ SNSLT 126_ KDSMN 131_ IKAHI 136_ HMLLE 141_ GLREL 146_ QGLQN 151_FPEKP
1: Involved in gene transcription regulation (PubMed:21730289, PubMed:28106301). Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription (PubMed:11854421, PubMed:21730289). Together with URI1, associates with chromatin to the NKX3-1 promoter region (PubMed:21730289). Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm (PubMed:28106301). May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity (PubMed:17620405, PubMed:21307340). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:17554592). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584)
2: Plays a role in protecting cells against TNF-alpha-induced apoptosis by preventing the recruitment of FADD and caspase 8 to the apoptotic complex I, composed of TRADD, TRAF2 and RIPK1/RIP