Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein)
1_MAAAG 6_ AGPGQ 11_ EAGAG 16_ PGPGA 21_ VANAT 26_ GAEEG 31_ EMKPV 36_ AAGAA 41_ APPGE 46_ GISAA 51_ PTVEP 56_ SSGEA 61_ EGGEA 66_ NLVDV 71_ SGGLE 76_ TESSN 81_ GKDTL 86_ EGAGD 91_ TSEVM 96_ DTQAG 101_ SVDEE 106_ NGRQL 111_ GEVEL 116_ QCGIC 121_ TKWFT 126_ ADTFG 131_ IDTSS 136_ CLPFM 141_ TNYSF 146_ HCNVC 151_ HHSGN 156_ TYFLR 161_ KQANL 166_ KEMCL 171_ SALAN 176_ LTWQS 181_ RTQDE 186_ HPKTM 191_ FSKDK 196_ DIIPF 201_ IDKYW 206_ ECMTT 211_ RQRPG 216_ KMTWP 221_ NNIVK 226_ TMSKE 231_ RDVFL 236_ VKEHP 241_ DPGSK 246_ DPEED 251_ YPKFG 256_ LLDQD 261_ LSNIG 266_ PAYDN 271_ QKQSS 276_ AVSTS 281_ GNLNG 286_ GIAAG 291_ SSGKG 296_ RGAKR 301_ KQQDG 306_ GTTGT 311_ TKKAR 316_ SDPLF 321_ SAQRL 326_ PPHGY 331_ PLEHP 336_ FNKDG 341_ YRYIL 346_ AEPDP 351_ HAPDP 356_ EKLEL 361_ DCWAG 366_ KPIPG 371_ DLYRA 376_ CLYER 381_ VLLAL 386_ HDRAP 391_ QLKIS 396_ DDRLT 401_ VVGEK 406_ GYSMV 411_ RASHG 416_ VRKGA 421_ WYFEI 426_ TVDEM 431_ PPDTA 436_ ARLGW 441_ SQPLG 446_ NLQAP 451_ LGYDK 456_ FSYSW 461_ RSKKG 466_ TKFHQ 471_ SIGKH 476_ YSSGY 481_ GQGDV 486_ LGFYI 491_ NLPED 496_ TETAK 501_ SLPDT 506_ YKDKA 511_ LIKFK 516_ SYLYF 521_ EEKDF 526_ VDKAE 531_ KSLKQ 536_ TPHSE 541_ IIFYK 546_ NGVNQ 551_ GVAYK 556_ DIFEG 561_ VYFPA 566_ ISLYK 571_ SCTVS 576_ INFGP 581_ CFKYP 586_ PKDLT 591_ YRPMS 596_ DMGWG 601_ AVVEH 606_ TLADV 611_ LYHVE 616_ TEVDG 621_RRSPP
1: Transcriptional regulator (PubMed:12670868). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (PubMed:19556245). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). May play a role in hematopoiesis (PubMed:12670868). In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653)