Gene name: TNFRSF10D

Uniprot entry:

Q9UBN6

Protein names:

Tumor necrosis factor receptor superfamily member 10D (Decoy receptor 2) (DcR2) (TNF-related apoptosis-inducing ligand receptor 4) (TRAIL receptor 4) (TRAIL-R4) (TRAIL receptor with a truncated death domain) (CD antigen CD264)

Protein sequence:

1_MGLWG 6_ QSVPT 11_ ASSAR 16_ AGRYP 21_ GARTA 26_ SGTRP 31_ WLLDP 36_ KILKF 41_ VVFIV 46_ AVLLP 51_ VRVDS 56_ ATIPR 61_ QDEVP 66_ QQTVA 71_ PQQQR 76_ RSLKE 81_ EECPA 86_ GSHRS 91_ EYTGA 96_ CNPCT 101_ EGVDY 106_ TIASN 111_ NLPSC 116_ LLCTV 121_ CKSGQ 126_ TNKSS 131_ CTTTR 136_ DTVCQ 141_ CEKGS 146_ FQDKN 151_ SPEMC 156_ RTCRT 161_ GCPRG 166_ MVKVS 171_ NCTPR 176_ SDIKC 181_ KNESA 186_ ASSTG 191_ KTPAA 196_ EETVT 201_ TILGM 206_ LASPY 211_ HYLII 216_ IVVLV 221_ IILAV 226_ VVVGF 231_ SCRKK 236_ FISYL 241_ KGICS 246_ GGGGG 251_ PERVH 256_ RVLFR 261_ RRSCP 266_ SRVPG 271_ AEDNA 276_ RNETL 281_ SNRYL 286_ QPTQV 291_ SEQEI 296_ QGQEL 301_ AELTG 306_ VTVEL 311_ PEEPQ 316_ RLLEQ 321_ AEAEG 326_ CQRRR 331_ LLVPV 336_ NDADS 341_ ADIST 346_ LLDAS 351_ ATLEE 356_ GHAKE 361_ TIQDQ 366_ LVGSE 371_ KLFYE 376_ EDEAG 381_SATSC

Protein annotations

Protein functions:

1: Receptor for the cytotoxic ligand TRAIL (PubMed:9430226). Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis (PubMed:9537512). Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway (PubMed:9382840, PubMed:9430226)