Histone deacetylase 6 (HD6) (EC 3.5.1.98) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-)
1_MTSTG 6_ QDSTT 11_ TRQRR 16_ SRQNP 21_ QSPPQ 26_ DSSVT 31_ SKRNI 36_ KKGAV 41_ PRSIP 46_ NLAEV 51_ KKKGK 56_ MKKLG 61_ QAMEE 66_ DLIVG 71_ LQGMD 76_ LNLEA 81_ EALAG 86_ TGLVL 91_ DEQLN 96_ EFHCL 101_ WDDSF 106_ PEGPE 111_ RLHAI 116_ KEQLI 121_ QEGLL 126_ DRCVS 131_ FQARF 136_ AEKEE 141_ LMLVH 146_ SLEYI 151_ DLMET 156_ TQYMN 161_ EGELR 166_ VLADT 171_ YDSVY 176_ LHPNS 181_ YSCAC 186_ LASGS 191_ VLRLV 196_ DAVLG 201_ AEIRN 206_ GMAII 211_ RPPGH 216_ HAQHS 221_ LMDGY 226_ CMFNH 231_ VAVAA 236_ RYAQQ 241_ KHRIR 246_ RVLIV 251_ DWDVH 256_ HGQGT 261_ QFTFD 266_ QDPSV 271_ LYFSI 276_ HRYEQ 281_ GRFWP 286_ HLKAS 291_ NWSTT 296_ GFGQG 301_ QGYTI 306_ NVPWN 311_ QVGMR 316_ DADYI 321_ AAFLH 326_ VLLPV 331_ ALEFQ 336_ PQLVL 341_ VAAGF 346_ DALQG 351_ DPKGE 356_ MAATP 361_ AGFAQ 366_ LTHLL 371_ MGLAG 376_ GKLIL 381_ SLEGG 386_ YNLRA 391_ LAEGV 396_ SASLH 401_ TLLGD 406_ PCPML 411_ ESPGA 416_ PCRSA 421_ QASVS 426_ CALEA 431_ LEPFW 436_ EVLVR 441_ STETV 446_ ERDNM 451_ EEDNV 456_ EESEE 461_ EGPWE 466_ PPVLP 471_ ILTWP 476_ VLQSR 481_ TGLVY 486_ DQNMM 491_ NHCNL 496_ WDSHH 501_ PEVPQ 506_ RILRI 511_ MCRLE 516_ ELGLA 521_ GRCLT 526_ LTPRP 531_ ATEAE 536_ LLTCH 541_ SAEYV 546_ GHLRA 551_ TEKMK 556_ TRELH 561_ RESSN 566_ FDSIY 571_ ICPST 576_ FACAQ 581_ LATGA 586_ ACRLV 591_ EAVLS 596_ GEVLN 601_ GAAVV 606_ RPPGH 611_ HAEQD 616_ AACGF 621_ CFFNS 626_ VAVAA 631_ RHAQT 636_ ISGHA 641_ LRILI 646_ VDWDV 651_ HHGNG 656_ TQHMF 661_ EDDPS 666_ VLYVS 671_ LHRYD 676_ HGTFF 681_ PMGDE 686_ GASSQ 691_ IGRAA 696_ GTGFT 701_ VNVAW 706_ NGPRM 711_ GDADY 716_ LAAWH 721_ RLVLP 726_ IAYEF 731_ NPELV 736_ LVSAG 741_ FDAAR 746_ GDPLG 751_ GCQVS 756_ PEGYA 761_ HLTHL 766_ LMGLA 771_ SGRII 776_ LILEG 781_ GYNLT 786_ SISES 791_ MAACT 796_ RSLLG 801_ DPPPL 806_ LTLPR 811_ PPLSG 816_ ALASI 821_ TETIQ 826_ VHRRY 831_ WRSLR 836_ VMKVE 841_ DREGP 846_ SSSKL 851_ VTKKA 856_ PQPAK 861_ PRLAE 866_ RMTTR 871_ EKKVL 876_ EAGMG 881_ KVTSA 886_ SFGEE 891_ STPGQ 896_ TNSET 901_ AVVAL 906_ TQDQP 911_ SEAAT 916_ GGATL 921_ AQTIS 926_ EAAIG 931_ GAMLG 936_ QTTSE 941_ EAVGG 946_ ATPDQ 951_ TTSEE 956_ TVGGA 961_ ILDQT 966_ TSEDA 971_ VGGAT 976_ LGQTT 981_ SEEAV 986_ GGATL 991_ AQTTS 996_ EAAME 1001_ GATLD 1006_ QTTSE 1011_ EAPGG 1016_ TELIQ 1021_ TPLAS 1026_ STDHQ 1031_ TPPTS 1036_ PVQGT 1041_ TPQIS 1046_ PSTLI 1051_ GSLRT 1056_ LELGS 1061_ ESQGA 1066_ SESQA 1071_ PGEEN 1076_ LLGEA 1081_ AGGQD 1086_ MADSM 1091_ LMQGS 1096_ RGLTD 1101_ QAIFY 1106_ AVTPL 1111_ PWCPH 1116_ LVAVC 1121_ PIPAA 1126_ GLDVT 1131_ QPCGD 1136_ CGTIQ 1141_ ENWVC 1146_ LSCYQ 1151_ VYCGR 1156_ YINGH 1161_ MLQHH 1166_ GNSGH 1171_ PLVLS 1176_ YIDLS 1181_ AWCYY 1186_ CQAYV 1191_ HHQAL 1196_ LDVKN 1201_ IAHQN 1206_KFGED
1: Deacetylates a wide range of non-histone substrates (PubMed:12024216, PubMed:18606987, PubMed:20308065, PubMed:24882211, PubMed:26246421, PubMed:30538141, PubMed:31857589, PubMed:30770470, PubMed:38534334, PubMed:39567688). Plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (PubMed:12024216, PubMed:20308065, PubMed:26246421). Required for cilia disassembly via deacetylation of alpha-tubulin (PubMed:17604723, PubMed:26246421). Alpha-tubulin deacetylation results in destabilization of dynamic microtubules (By similarity). Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed:30538141). Deacetylates SQSTM1 (PubMed:31857589). Deacetylates peroxiredoxins PRDX1 and PRDX2, decreasing their reducing activity (PubMed:18606987). Deacetylates antiviral protein RIGI in the presence of viral mRNAs which is required for viral RNA detection by RIGI (By similarity). Sequentially deacetylates and polyubiquitinates DNA mismatch repair protein MSH2 which leads to MSH2 degradation, reducing cellular sensitivity to DNA-damaging agents and decreasing cellular DNA mismatch repair activities (PubMed:24882211). Deacetylates DNA mismatch repair protein MLH1 which prevents recruitment of the MutL alpha complex (formed by the MLH1-PMS2 heterodimer) to the MutS alpha complex (formed by the MSH2-MSH6 heterodimer), leading to tolerance of DNA damage (PubMed:30770470). Deacetylates RHOT1/MIRO1 which blocks mitochondrial transport and mediates axon growth inhibition (By similarity). Deacetylates transcription factor SP1 which leads to increased expression of ENG, positively regulating angiogenesis (PubMed:38534334). Deacetylates KHDRBS1/SAM68 which regulates alternative splicing by inhibiting the inclusion of CD44 alternate exons (PubMed:26080397). Acts as a valine sensor by binding to valine through the primate-specific SE14 repeat region (PubMed:39567688). In valine deprivation conditions, translocates from the cytoplasm to the nucleus where it deacetylates TET2 which promotes TET2-dependent DNA demethylation, leading to DNA damage (PubMed:39567688). Promotes odontoblast differentiation following IPO7-mediated nuclear import and subsequent repression of RUNX2 expression (By similarity). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (PubMed:17846173). Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and targets them to the aggresome, facilitating their clearance by autophagy (PubMed:17846173). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532)
2: (Microbial infection) Deacetylates the SARS-CoV-2 N protein which promotes association of the viral N protein with human G3BP1, leading to disruption of cellular stress granule formation and facilitating viral replication