Dickkopf-related protein 3 (Dickkopf-3) (Dkk-3) (hDkk-3)
1_MQRLG 6_ ATLLC 11_ LLLAA 16_ AVPTA 21_ PAPAP 26_ TATSA 31_ PVKPG 36_ PALSY 41_ PQEEA 46_ TLNEM 51_ FREVE 56_ ELMED 61_ TQHKL 66_ RSAVE 71_ EMEAE 76_ EAAAK 81_ ASSEV 86_ NLANL 91_ PPSYH 96_ NETNT 101_ DTKVG 106_ NNTIH 111_ VHREI 116_ HKITN 121_ NQTGQ 126_ MVFSE 131_ TVITS 136_ VGDEE 141_ GRRSH 146_ ECIID 151_ EDCGP 156_ SMYCQ 161_ FASFQ 166_ YTCQP 171_ CRGQR 176_ MLCTR 181_ DSECC 186_ GDQLC 191_ VWGHC 196_ TKMAT 201_ RGSNG 206_ TICDN 211_ QRDCQ 216_ PGLCC 221_ AFQRG 226_ LLFPV 231_ CTPLP 236_ VEGEL 241_ CHDPA 246_ SRLLD 251_ LITWE 256_ LEPDG 261_ ALDRC 266_ PCASG 271_ LLCQP 276_ HSHSL 281_ VYVCK 286_ PTFVG 291_ SRDQD 296_ GEILL 301_ PREVP 306_ DEYEV 311_ GSFME 316_ EVRQE 321_ LEDLE 326_ RSLTE 331_ EMALR 336_ EPAAA 341_AAALL
1: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity)