LIM/homeobox protein Lhx3 (LIM homeobox protein 3)
1_MLLET 6_ GLERD 11_ RARPG 16_ AAAVC 21_ TLGGT 26_ REIPL 31_ CAGCD 36_ QHILD 41_ RFILK 46_ ALDRH 51_ WHSKC 56_ LKCSD 61_ CHTPL 66_ AERCF 71_ SRGES 76_ VYCKD 81_ DFFKR 86_ FGTKC 91_ AACQL 96_ GIPPT 101_ QVVRR 106_ AQDFV 111_ YHLHC 116_ FACVV 121_ CKRQL 126_ ATGDE 131_ FYLME 136_ DSRLV 141_ CKADY 146_ ETAKQ 151_ REAEA 156_ TAKRP 161_ RTTIT 166_ AKQLE 171_ TLKSA 176_ YNTSP 181_ KPARH 186_ VREQL 191_ SSETG 196_ LDMRV 201_ VQVWF 206_ QNRRA 211_ KEKRL 216_ KKDAG 221_ RQRWG 226_ QYFRN 231_ MKRSR 236_ GGSKS 241_ DKDSV 246_ QEGQD 251_ SDAEV 256_ SFPDE 261_ PSLAE 266_ MGPAN 271_ GLYGS 276_ LGEPT 281_ QALGR 286_ PSGAL 291_ GNFSL 296_ EHGGL 301_ AGPEQ 306_ YRELR 311_ PGSPY 316_ GVPPS 321_ PAAPQ 326_ SLPGP 331_ QPLLS 336_ SLVYP 341_ DTSLG 346_ LVPSG 351_ APGGP 356_ PPMRV 361_ LAGNG 366_ PSSDL 371_ STGSS 376_ GGYPD 381_ FPASP 386_ ASWLD 391_EVDHA
1: Transcription factor. Recognizes and binds to the consensus sequence motif 5'-AATTAATTA-3' in the regulatory elements of target genes, such as glycoprotein hormones alpha chain CGA and visual system homeobox CHX10, positively modulating transcription; transcription can be co-activated by LDB2. Synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system (PubMed:21149718). Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1 (By similarity)