DnaJ homolog subfamily B member 11 (APOBEC1-binding protein 2) (ABBP-2) (DnaJ protein homolog 9) (ER-associated DNAJ) (ER-associated Hsp40 co-chaperone) (Endoplasmic reticulum DNA J domain-containing protein 3) (ER-resident protein ERdj3) (ERdj3) (ERj3p) (HEDJ) (Human DnaJ protein 9) (hDj-9) (PWP1-interacting protein 4)
1_MAPQN 6_ LSTFC 11_ LLLLY 16_ LIGAV 21_ IAGRD 26_ FYKIL 31_ GVPRS 36_ ASIKD 41_ IKKAY 46_ RKLAL 51_ QLHPD 56_ RNPDD 61_ PQAQE 66_ KFQDL 71_ GAAYE 76_ VLSDS 81_ EKRKQ 86_ YDTYG 91_ EEGLK 96_ DGHQS 101_ SHGDI 106_ FSHFF 111_ GDFGF 116_ MFGGT 121_ PRQQD 126_ RNIPR 131_ GSDII 136_ VDLEV 141_ TLEEV 146_ YAGNF 151_ VEVVR 156_ NKPVA 161_ RQAPG 166_ KRKCN 171_ CRQEM 176_ RTTQL 181_ GPGRF 186_ QMTQE 191_ VVCDE 196_ CPNVK 201_ LVNEE 206_ RTLEV 211_ EIEPG 216_ VRDGM 221_ EYPFI 226_ GEGEP 231_ HVDGE 236_ PGDLR 241_ FRIKV 246_ VKHPI 251_ FERRG 256_ DDLYT 261_ NVTIS 266_ LVESL 271_ VGFEM 276_ DITHL 281_ DGHKV 286_ HISRD 291_ KITRP 296_ GAKLW 301_ KKGEG 306_ LPNFD 311_ NNNIK 316_ GSLII 321_ TFDVD 326_ FPKEQ 331_ LTEEA 336_ REGIK 341_ QLLKQ 346_ GSVQK 351_VYNGL
1: As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins (PubMed:10827079, PubMed:15525676, PubMed:29706351). Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed (PubMed:15525676). May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity (PubMed:10827079). It is necessary for maturation and correct trafficking of PKD1 (PubMed:29706351)