Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1)
1_MLLLL 6_ LLAPL 11_ FLRPP 16_ GAGGA 21_ QTPNA 26_ TSEGC 31_ QIIHP 36_ PWEGG 41_ IRYRG 46_ LTRDQ 51_ VKAIN 56_ FLPVD 61_ YEIEY 66_ VCRGE 71_ REVVG 76_ PKVRK 81_ CLANG 86_ SWTDM 91_ DTPSR 96_ CVRIC 101_ SKSYL 106_ TLENG 111_ KVFLT 116_ GGDLP 121_ ALDGA 126_ RVDFR 131_ CDPDF 136_ HLVGS 141_ SRSIC 146_ SQGQW 151_ STPKP 156_ HCQVN 161_ RTPHS 166_ ERRAV 171_ YIGAL 176_ FPMSG 181_ GWPGG 186_ QACQP 191_ AVEMA 196_ LEDVN 201_ SRRDI 206_ LPDYE 211_ LKLIH 216_ HDSKC 221_ DPGQA 226_ TKYLY 231_ ELLYN 236_ DPIKI 241_ ILMPG 246_ CSSVS 251_ TLVAE 256_ AARMW 261_ NLIVL 266_ SYGSS 271_ SPALS 276_ NRQRF 281_ PTFFR 286_ THPSA 291_ TLHNP 296_ TRVKL 301_ FEKWG 306_ WKKIA 311_ TIQQT 316_ TEVFT 321_ STLDD 326_ LEERV 331_ KEAGI 336_ EITFR 341_ QSFFS 346_ DPAVP 351_ VKNLK 356_ RQDAR 361_ IIVGL 366_ FYETE 371_ ARKVF 376_ CEVYK 381_ ERLFG 386_ KKYVW 391_ FLIGW 396_ YADNW 401_ FKIYD 406_ PSINC 411_ TVDEM 416_ TEAVE 421_ GHITT 426_ EIVML 431_ NPANT 436_ RSISN 441_ MTSQE 446_ FVEKL 451_ TKRLK 456_ RHPEE 461_ TGGFQ 466_ EAPLA 471_ YDAIW 476_ ALALA 481_ LNKTS 486_ GGGGR 491_ SGVRL 496_ EDFNY 501_ NNQTI 506_ TDQIY 511_ RAMNS 516_ SSFEG 521_ VSGHV 526_ VFDAS 531_ GSRMA 536_ WTLIE 541_ QLQGG 546_ SYKKI 551_ GYYDS 556_ TKDDL 561_ SWSKT 566_ DKWIG 571_ GSPPA 576_ DQTLV 581_ IKTFR 586_ FLSQK 591_ LFISV 596_ SVLSS 601_ LGIVL 606_ AVVCL 611_ SFNIY 616_ NSHVR 621_ YIQNS 626_ QPNLN 631_ NLTAV 636_ GCSLA 641_ LAAVF 646_ PLGLD 651_ GYHIG 656_ RNQFP 661_ FVCQA 666_ RLWLL 671_ GLGFS 676_ LGYGS 681_ MFTKI 686_ WWVHT 691_ VFTKK 696_ EEKKE 701_ WRKTL 706_ EPWKL 711_ YATVG 716_ LLVGM 721_ DVLTL 726_ AIWQI 731_ VDPLH 736_ RTIET 741_ FAKEE 746_ PKEDI 751_ DVSIL 756_ PQLEH 761_ CSSRK 766_ MNTWL 771_ GIFYG 776_ YKGLL 781_ LLLGI 786_ FLAYE 791_ TKSVS 796_ TEKIN 801_ DHRAV 806_ GMAIY 811_ NVAVL 816_ CLITA 821_ PVTMI 826_ LSSQQ 831_ DAAFA 836_ FASLA 841_ IVFSS 846_ YITLV 851_ VLFVP 856_ KMRRL 861_ ITRGE 866_ WQSEA 871_ QDTMK 876_ TGSST 881_ NNNEE 886_ EKSRL 891_ LEKEN 896_ RELEK 901_ IIAEK 906_ EERVS 911_ ELRHQ 916_ LQSRQ 921_ QLRSR 926_ RHPPT 931_ PPEPS 936_ GGLPR 941_ GPPEP 946_ PDRLS 951_ CDGSR 956_VHLLY
1: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054, PubMed:36103875, PubMed:9872316, PubMed:9872744). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10773016, PubMed:10906333, PubMed:24305054, PubMed:9872744). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644). Calcium is required for high affinity binding to GABA (By similarity). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9844003). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:10075644, PubMed:22660477, PubMed:9844003, PubMed:9872316, PubMed:9872744). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). Activated by (-)-baclofen, cgp27492 and blocked by phaclofen (PubMed:24305054, PubMed:9844003, PubMed:9872316)
2: Isoform 1E may regulate the formation of functional GABBR1/GABBR2 heterodimers by competing for GABBR2 binding. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites