E3 ubiquitin-protein ligase RNF14 (EC 2.3.2.31) (Androgen receptor-associated protein 54) (HFB30) (RING finger protein 14) (Triad2 protein)
1_MSSED 6_ REAQE 11_ DELLA 16_ LASIY 21_ DGDEF 26_ RKAES 31_ VQGGE 36_ TRIYL 41_ DLPQN 46_ FKIFV 51_ SGNSN 56_ ECLQN 61_ SGFEY 66_ TICFL 71_ PPLVL 76_ NFELP 81_ PDYPS 86_ SSPPS 91_ FTLSG 96_ KWLSP 101_ TQLSA 106_ LCKHL 111_ DNLWE 116_ EHRGS 121_ VVLFA 126_ WMQFL 131_ KEETL 136_ AYLNI 141_ VSPFE 146_ LKIGS 151_ QKKVQ 156_ RRTAQ 161_ ASPNT 166_ ELDFG 171_ GAAGS 176_ DVDQE 181_ EIVDE 186_ RAVQD 191_ VESLS 196_ NLIQE 201_ ILDFD 206_ QAQQI 211_ KCFNS 216_ KLFLC 221_ SICFC 226_ EKLGS 231_ ECMYF 236_ LECRH 241_ VYCKA 246_ CLKDY 251_ FEIQI 256_ RDGQV 261_ QCLNC 266_ PEPKC 271_ PSVAT 276_ PGQVK 281_ ELVEA 286_ ELFAR 291_ YDRLL 296_ LQSSL 301_ DLMAD 306_ VVYCP 311_ RPCCQ 316_ LPVMQ 321_ EPGCT 326_ MGICS 331_ SCNFA 336_ FCTLC 341_ RLTYH 346_ GVSPC 351_ KVTAE 356_ KLMDL 361_ RNEYL 366_ QADEA 371_ NKRLL 376_ DQRYG 381_ KRVIQ 386_ KALEE 391_ MESKE 396_ WLEKN 401_ SKSCP 406_ CCGTP 411_ IEKLD 416_ GCNKM 421_ TCTGC 426_ MQYFC 431_ WICMG 436_ SLSRA 441_ NPYKH 446_ FNDPG 451_ SPCFN 456_ RLFYA 461_ VDVDD 466_DIWED
1: E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (PubMed:36638793, PubMed:37651229, PubMed:37951215, PubMed:37951216). Recruited to stalled ribosomes by the ribosome collision sensor GCN1 and mediates 'Lys-6'-linked ubiquitination of target proteins, leading to their degradation (PubMed:36638793, PubMed:37651229, PubMed:37951215, PubMed:37951216). Mediates ubiquitination of EEF1A1/eEF1A and ETF1/eRF1 translation factors on stalled ribosomes, leading to their degradation (PubMed:36638793, PubMed:37651229). Also catalyzes ubiquitination of ribosomal proteins RPL0, RPL1, RPL12, RPS13 and RPS17 (PubMed:36638793). Specifically required to resolve RNA-protein cross-links caused by reactive aldehydes, which trigger translation stress by stalling ribosomes: acts by catalying 'Lys-6'-linked ubiquitination of RNA-protein cross-links, leading to their removal by the ATP-dependent unfoldase VCP and subsequent degradation by the proteasome (PubMed:37951215, PubMed:37951216). Independently of its function in the response to stalled ribosomes, acts as a regulator of transcription in Wnt signaling via its interaction with TCF transcription factors (TCF7/TCF1, TCF7L1/TCF3 and TCF7L2/TCF4) (PubMed:23449499). May also play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription (PubMed:19345326)