SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2)
1_MALSR 6_ GLPRE 11_ LAEAV 16_ AGGRV 21_ LVVGA 26_ GGIGC 31_ ELLKN 36_ LVLTG 41_ FSHID 46_ LIDLD 51_ TIDVS 56_ NLNRQ 61_ FLFQK 66_ KHVGR 71_ SKAQV 76_ AKESV 81_ LQFYP 86_ KANIV 91_ AYHDS 96_ IMNPD 101_ YNVEF 106_ FRQFI 111_ LVMNA 116_ LDNRA 121_ ARNHV 126_ NRMCL 131_ AADVP 136_ LIESG 141_ TAGYL 146_ GQVTT 151_ IKKGV 156_ TECYE 161_ CHPKP 166_ TQRTF 171_ PGCTI 176_ RNTPS 181_ EPIHC 186_ IVWAK 191_ YLFNQ 196_ LFGEE 201_ DADQE 206_ VSPDR 211_ ADPEA 216_ AWEPT 221_ EAEAR 226_ ARASN 231_ EDGDI 236_ KRIST 241_ KEWAK 246_ STGYD 251_ PVKLF 256_ TKLFK 261_ DDIRY 266_ LLTMD 271_ KLWRK 276_ RKPPV 281_ PLDWA 286_ EVQSQ 291_ GEETN 296_ ASDQQ 301_ NEPQL 306_ GLKDQ 311_ QVLDV 316_ KSYAR 321_ LFSKS 326_ IETLR 331_ VHLAE 336_ KGDGA 341_ ELIWD 346_ KDDPS 351_ AMDFV 356_ TSAAN 361_ LRMHI 366_ FSMNM 371_ KSRFD 376_ IKSMA 381_ GNIIP 386_ AIATT 391_ NAVIA 396_ GLIVL 401_ EGLKI 406_ LSGKI 411_ DQCRT 416_ IFLNK 421_ QPNPR 426_ KKLLV 431_ PCALD 436_ PPNPN 441_ CYVCA 446_ SKPEV 451_ TVRLN 456_ VHKVT 461_ VLTLQ 466_ DKIVK 471_ EKFAM 476_ VAPDV 481_ QIEDG 486_ KGTIL 491_ ISSEE 496_ GETEA 501_ NNHKK 506_ LSEFG 511_ IRNGS 516_ RLQAD 521_ DFLQD 526_ YTLLI 531_ NILHS 536_ EDLGK 541_ DVEFE 546_ VVGDA 551_ PEKVG 556_ PKQAE 561_ DAAKS 566_ ITNGS 571_ DDGAQ 576_ PSTST 581_ AQEQD 586_ DVLIV 591_ DSDEE 596_ DSSNN 601_ ADVSE 606_ EERSR 611_ KRKLD 616_ EKENL 621_ SAKRS 626_ RIEQK 631_EELDD
1: The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2