Dickkopf-related protein 4 (Dickkopf-4) (Dkk-4) (hDkk-4) [Cleaved into: Dickkopf-related protein 4 short form]
1_MVAAV 6_ LLGLS 11_ WLCSP 16_ LGALV 21_ LDFNN 26_ IRSSA 31_ DLHGA 36_ RKGSQ 41_ CLSDT 46_ DCNTR 51_ KFCLQ 56_ PRDEK 61_ PFCAT 66_ CRGLR 71_ RRCQR 76_ DAMCC 81_ PGTLC 86_ VNDVC 91_ TTMED 96_ ATPIL 101_ ERQLD 106_ EQDGT 111_ HAEGT 116_ TGHPV 121_ QENQP 126_ KRKPS 131_ IKKSQ 136_ GRKGQ 141_ EGESC 146_ LRTFD 151_ CGPGL 156_ CCARH 161_ FWTKI 166_ CKPVL 171_ LEGQV 176_ CSRRG 181_ HKDTA 186_ QAPEI 191_ FQRCD 196_ CGPGL 201_ LCRSQ 206_ LTSNR 211_ QHARL 216_RVCQK
1: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity)