DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP)
1_MDSTK 6_ EKCDS 11_ YKDDL 16_ LLRMG 21_ LNDNK 26_ AGMEG 31_ LDKEK 36_ INKII 41_ MEATK 46_ GSRFY 51_ GNELK 56_ KEKQV 61_ NQRIE 66_ NMMQQ 71_ KAQIT 76_ SQQLR 81_ KAQLQ 86_ VDRFA 91_ MELEQ 96_ SRNLS 101_ NTIVH 106_ IDMDA 111_ FYAAV 116_ EMRDN 121_ PELKD 126_ KPIAV 131_ GSMSM 136_ LSTSN 141_ YHARR 146_ FGVRA 151_ AMPGF 156_ IAKRL 161_ CPQLI 166_ IVPPN 171_ FDKYR 176_ AVSKE 181_ VKEIL 186_ ADYDP 191_ NFMAM 196_ SLDEA 201_ YLNIT 206_ KHLEE 211_ RQNWP 216_ EDKRR 221_ YFIKM 226_ GSSVE 231_ NDNPG 236_ KEVNK 241_ LSEHE 246_ RSISP 251_ LLFEE 256_ SPSDV 261_ QPPGD 266_ PFQVN 271_ FEEQN 276_ NPQIL 281_ QNSVV 286_ FGTSA 291_ QEVVK 296_ EIRFR 301_ IEQKT 306_ TLTAS 311_ AGIAP 316_ NTMLA 321_ KVCSD 326_ KNKPN 331_ GQYQI 336_ LPNRQ 341_ AVMDF 346_ IKDLP 351_ IRKVS 356_ GIGKV 361_ TEKML 366_ KALGI 371_ ITCTE 376_ LYQQR 381_ ALLSL 386_ LFSET 391_ SWHYF 396_ LHISL 401_ GLGST 406_ HLTRD 411_ GERKS 416_ MSVER 421_ TFSEI 426_ NKAEE 431_ QYSLC 436_ QELCS 441_ ELAQD 446_ LQKER 451_ LKGRT 456_ VTIKL 461_ KNVNF 466_ EVKTR 471_ ASTVS 476_ SVVST 481_ AEEIF 486_ AIAKE 491_ LLKTE 496_ IDADF 501_ PHPLR 506_ LRLMG 511_ VRISS 516_ FPNEE 521_ DRKHQ 526_ QRSII 531_ GFLQA 536_ GNQAL 541_ SATEC 546_ TLEKT 551_ DKDKF 556_ VKPLE 561_ MSHKK 566_ SFFDK 571_ KRSER 576_ KWSHQ 581_ DTFKC 586_ EAVNK 591_ QSFQT 596_ SQPFQ 601_ VLKKK 606_ MNENL 611_ EISEN 616_ SDDCQ 621_ ILTCP 626_ VCFRA 631_ QGCIS 636_ LEALN 641_ KHVDE 646_ CLDGP 651_ SISEN 656_ FKMFS 661_ CSHVS 666_ ATKVN 671_ KKENV 676_ PASSL 681_ CEKQD 686_ YEAHP 691_ KIKEI 696_ SSVDC 701_ IALVD 706_ TIDNS 711_ SKAES 716_ IDALS 721_ NKHSK 726_ EECSS 731_ LPSKS 736_ FNIEH 741_ CHQNS 746_ SSTVS 751_ LENED 756_ VGSFR 761_ QEYRQ 766_ PYLCE 771_ VKTGQ 776_ ALVCP 781_ VCNVE 786_ QKTSD 791_ LTLFN 796_ VHVDV 801_ CLNKS 806_ FIQEL 811_ RKDKF 816_ NPVNQ 821_ PKESS 826_ RSTGS 831_ SSGVQ 836_ KAVTR 841_ TKRPG 846_ LMTKY 851_ STSKK 856_ IKPNN 861_PKHTL
1: DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity