Dickkopf-related protein 2 (Dickkopf-2) (Dkk-2) (hDkk-2)
1_MAALM 6_ RSKDS 11_ SCCLL 16_ LLAAV 21_ LMVES 26_ SQIGS 31_ SRAKL 36_ NSIKS 41_ SLGGE 46_ TPGQA 51_ ANRSA 56_ GMYQG 61_ LAFGG 66_ SKKGK 71_ NLGQA 76_ YPCSS 81_ DKECE 86_ VGRYC 91_ HSPHQ 96_ GSSAC 101_ MVCRR 106_ KKKRC 111_ HRDGM 116_ CCPST 121_ RCNNG 126_ ICIPV 131_ TESIL 136_ TPHIP 141_ ALDGT 146_ RHRDR 151_ NHGHY 156_ SNHDL 161_ GWQNL 166_ GRPHT 171_ KMSHI 176_ KGHEG 181_ DPCLR 186_ SSDCI 191_ EGFCC 196_ ARHFW 201_ TKICK 206_ PVLHQ 211_ GEVCT 216_ KQRKK 221_ GSHGL 226_ EIFQR 231_ CDCAK 236_ GLSCK 241_ VWKDA 246_ TYSSK 251_ARLHV
1: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity)