Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1)
1_MNSGA 6_ MRIHS 11_ KGHFQ 16_ GGIQV 21_ KNEKN 26_ RPSLK 31_ SLKTD 36_ NRPEK 41_ SKCKP 46_ LWGKV 51_ FYLDL 56_ PSVTI 61_ SEKLQ 66_ KDIKD 71_ LGGRV 76_ EEFLS 81_ KDISY 86_ LISNK 91_ KEAKF 96_ AQTLG 101_ RISPV 106_ PSPES 111_ AYTAE 116_ TTSPH 121_ PSHDG 126_ SSFKS 131_ PDTVC 136_ LSRGK 141_ LLVEK 146_ AIKDH 151_ DFIPS 156_ NSILS 161_ NALSW 166_ GVKIL 171_ HIDDI 176_ RYYIE 181_ QKKKE 186_ LYLLK 191_ KSSTS 196_ VRDGG 201_ KRVGS 206_ GAQKT 211_ RTGRL 216_ KKPFV 221_ KVEDM 226_ SQLYR 231_ PFYLQ 236_ LTNMP 241_ FINYS 246_ IQKPC 251_ SPFDV 256_ DKPSS 261_ MQKQT 266_ QVKLR 271_ IQTDG 276_ DKYGG 281_ TSIQL 286_ QLKEK 291_ KKKGY 296_ CECCL 301_ QKYED 306_ LETHL 311_ LSEQH 316_ RNFAQ 321_ SNQYQ 326_ VVDDI 331_ VSKLV 336_ FDFVE 341_ YEKDT 346_ PKKKR 351_ IKYSV 356_ GSLSP 361_ VSASV 366_ LKKTE 371_ QKEKV 376_ ELQHI 381_ SQKDC 386_ QEDDT 391_ TVKEQ 396_ NFLYK 401_ ETQET 406_ EKKLL 411_ FISEP 416_ IPHPS 421_ NELRG 426_ LNEKM 431_ SNKCS 436_ MLSTA 441_ EDDIR 446_ QNFTQ 451_ LPLHK 456_ NKQEC 461_ ILDIS 466_ EHTLS 471_ ENDLE 476_ ELRVD 481_ HYKCN 486_ IQASV 491_ HVSDF 496_ STDNS 501_ GSQPK 506_ QKSDT 511_ VLFPA 516_ KDLKE 521_ KDLHS 526_ IFTHD 531_ SGLIT 536_ INSSQ 541_ EHLTV 546_ QAKAP 551_ FHTPP 556_ EEPNE 561_ CDFKN 566_ MDSLP 571_ SGKIH 576_ RKVKI 581_ ILGRN 586_ RKENL 591_ EPNAE 596_ FDKRT 601_ EFITQ 606_ EENRI 611_ CSSPV 616_ QSLLD 621_ LFQTS 626_ EEKSE 631_ FLGFT 636_ SYTEK 641_ SGICN 646_ VLDIW 651_ EEENS 656_ DNLLT 661_ AFFSS 666_PSTST
1: Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle